Amphotericin B tissue penetration and pharmacokinetics in healthy and Candida albicans-infected rats: insights from microdialysis and population modeling

Amphotericin B tissue penetration and pharmacokinetics in healthy and Candida albicans-infected rats: insights from microdialysis and population modeling

IntroductionThis study evaluated the relationship between total plasma and free kidney concentrations of amphotericin B (AmB) in healthy and C. albicans-infected Wistar rats using microdialysis and has the potential to significantly impact future research in this field and promote the development of...

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Main Authors: Valdeene Vieira Santos, Laiz Campos Pereira, Jackeline Marley Santos de Araújo, Matheus Antônio da Hora Borges, Carolina Magalhães Brandão, Luisa Oliveira Santos, Cristiane Flora Villarreal, Francine Johansson Azeredo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
Amphotericin B
Candida albicans
population pharmacokinetic modeling
microdialysis
rats
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1515462/full
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