Beraprost’s Efficacy and Safety in the Treatment of Intermittent Claudicatio in Patients with Critical Limb Threatening Ischemia (CLTI)
Critical limb threatening ischemia (CLTI) is the most advanced stage of peripheral arterial diseases. Alternative treatment for claudication in CLTI patients is beraprost. We aim to review effectiveness and safety beraprost for relieve symptoms in CLTI. We conducted systematic literature searching u...
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2023-06-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
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| Online Access: | https://scholarhub.ui.ac.id/jpdi/vol10/iss2/6/ |
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| author | Andhika Pangestu Nur Asicha Rahmat Cahyanur Resultanti |
| author_facet | Andhika Pangestu Nur Asicha Rahmat Cahyanur Resultanti |
| author_sort | Andhika Pangestu |
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| description | Critical limb threatening ischemia (CLTI) is the most advanced stage of peripheral arterial diseases. Alternative treatment for claudication in CLTI patients is beraprost. We aim to review effectiveness and safety beraprost for relieve symptoms in CLTI. We conducted systematic literature searching using PubMed/MEDLINE, Embase, ProQuest, and Cochrane databases. Selected articles were examined for duplication and screened by abstract and title. Then, we appraised the articles based on the critical appraisal sheet from Centre for Evidence-Based Medicine (CEBM) University of Oxford. We found one systematic review-meta analysis (SR-MA) which involved 4,477 randomized participants. The results from this study are moderate quality evidence that prostanoids reduced rest pain (RR 1.30; 95%CI 1.06 – 1.59) and promoted ulcer healing (RR 1.24; 95%CI 1.04 – 1.48). In adult patients with CLTI and intermittent claudication as the primary complaint, vasodilator agents such as beraprost have a beneficial effect and a favorable therapeutic response. Numerous effects, including cardiovascular benefit, adverse events, resting pain relief, ulcer healing, outcome maximum walking distance (MWD), and pain-free walking distance, demonstrate the benefit (PFWD). The benefits of beraprost differ depending on the mechanism of action and pharmacokinetics of the drugs. |
| format | Article |
| id | doaj-art-3e63a38eae5b43c4b0238ad59c86b186 |
| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2023-06-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-3e63a38eae5b43c4b0238ad59c86b1862025-08-20T02:23:04ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212023-06-0110296101https://doi.org/10.7454/jpdi.v10i2.1415Beraprost’s Efficacy and Safety in the Treatment of Intermittent Claudicatio in Patients with Critical Limb Threatening Ischemia (CLTI) Andhika Pangestu0Nur Asicha1Rahmat Cahyanur2Resultanti3Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, JakartaKelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hematologi dan Onkologi Medik, Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo, JakartaDivisi Kardiologi, Kelompok Staf Medis Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo, JakartaCritical limb threatening ischemia (CLTI) is the most advanced stage of peripheral arterial diseases. Alternative treatment for claudication in CLTI patients is beraprost. We aim to review effectiveness and safety beraprost for relieve symptoms in CLTI. We conducted systematic literature searching using PubMed/MEDLINE, Embase, ProQuest, and Cochrane databases. Selected articles were examined for duplication and screened by abstract and title. Then, we appraised the articles based on the critical appraisal sheet from Centre for Evidence-Based Medicine (CEBM) University of Oxford. We found one systematic review-meta analysis (SR-MA) which involved 4,477 randomized participants. The results from this study are moderate quality evidence that prostanoids reduced rest pain (RR 1.30; 95%CI 1.06 – 1.59) and promoted ulcer healing (RR 1.24; 95%CI 1.04 – 1.48). In adult patients with CLTI and intermittent claudication as the primary complaint, vasodilator agents such as beraprost have a beneficial effect and a favorable therapeutic response. Numerous effects, including cardiovascular benefit, adverse events, resting pain relief, ulcer healing, outcome maximum walking distance (MWD), and pain-free walking distance, demonstrate the benefit (PFWD). The benefits of beraprost differ depending on the mechanism of action and pharmacokinetics of the drugs.https://scholarhub.ui.ac.id/jpdi/vol10/iss2/6/beraprostcltiintermittent claudicatio |
| spellingShingle | Andhika Pangestu Nur Asicha Rahmat Cahyanur Resultanti Beraprost’s Efficacy and Safety in the Treatment of Intermittent Claudicatio in Patients with Critical Limb Threatening Ischemia (CLTI) Jurnal Penyakit Dalam Indonesia beraprost clti intermittent claudicatio |
| title | Beraprost’s Efficacy and Safety in the Treatment of Intermittent Claudicatio in Patients with Critical Limb Threatening Ischemia (CLTI) |
| title_full | Beraprost’s Efficacy and Safety in the Treatment of Intermittent Claudicatio in Patients with Critical Limb Threatening Ischemia (CLTI) |
| title_fullStr | Beraprost’s Efficacy and Safety in the Treatment of Intermittent Claudicatio in Patients with Critical Limb Threatening Ischemia (CLTI) |
| title_full_unstemmed | Beraprost’s Efficacy and Safety in the Treatment of Intermittent Claudicatio in Patients with Critical Limb Threatening Ischemia (CLTI) |
| title_short | Beraprost’s Efficacy and Safety in the Treatment of Intermittent Claudicatio in Patients with Critical Limb Threatening Ischemia (CLTI) |
| title_sort | beraprost s efficacy and safety in the treatment of intermittent claudicatio in patients with critical limb threatening ischemia clti |
| topic | beraprost clti intermittent claudicatio |
| url | https://scholarhub.ui.ac.id/jpdi/vol10/iss2/6/ |
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