Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes
The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [M(eno)2(H2O)2]3H2O(M=CuII, NiII or MnII) and [M(eno)(H2O)2]Cl⋅4H2O (M=FeIII) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2009/914105 |
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| author | Saeed Arayne Najma Sultana Urooj Haroon M. Ahmed Mesaik |
| author_facet | Saeed Arayne Najma Sultana Urooj Haroon M. Ahmed Mesaik |
| author_sort | Saeed Arayne |
| collection | DOAJ |
| description | The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [M(eno)2(H2O)2]3H2O(M=CuII, NiII or MnII) and [M(eno)(H2O)2]Cl⋅4H2O (M=FeIII) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal complexes were also tested for their ability to scavenge reactive oxygen species where by MnII and CuII complexes exhibited potential to mediate anti-inflammatory response. |
| format | Article |
| id | doaj-art-3e61896351c849308b5cc7e2f492e98d |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-3e61896351c849308b5cc7e2f492e98d2025-02-03T06:01:25ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2009-01-01200910.1155/2009/914105914105Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal ComplexesSaeed Arayne0Najma Sultana1Urooj Haroon2M. Ahmed Mesaik3Department of Chemistry, University of Karachi, Karachi-75270, PakistanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, PakistanDepartment of Chemistry, University of Karachi, Karachi-75270, PakistanPCMD, International Centre of Chemical Sciences, University of Karachi, Karachi-75270, PakistanThe present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [M(eno)2(H2O)2]3H2O(M=CuII, NiII or MnII) and [M(eno)(H2O)2]Cl⋅4H2O (M=FeIII) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal complexes were also tested for their ability to scavenge reactive oxygen species where by MnII and CuII complexes exhibited potential to mediate anti-inflammatory response.http://dx.doi.org/10.1155/2009/914105 |
| spellingShingle | Saeed Arayne Najma Sultana Urooj Haroon M. Ahmed Mesaik Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes Bioinorganic Chemistry and Applications |
| title | Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes |
| title_full | Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes |
| title_fullStr | Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes |
| title_full_unstemmed | Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes |
| title_short | Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes |
| title_sort | synthesis characterization antibacterial and anti inflammatory activities of enoxacin metal complexes |
| url | http://dx.doi.org/10.1155/2009/914105 |
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