Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection
Glucose is the main source of energy in cellular metabolism and is essential for normal cellular function and growth. Abnormal glucose levels can lead to significant health issues, highlighting the importance of developing efficient, accessible, and precise glucose detection platform. Here, the Ti3C...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Sensing and Bio-Sensing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180425000662 |
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| author | Xuming Sun Mingyan Zhang Jinlong Chang Linyan Xie Qiongqiong Ren Wenshuai Jiang Zhen Jin Shiqi Pan Xiuli Yang Wu Ren |
| author_facet | Xuming Sun Mingyan Zhang Jinlong Chang Linyan Xie Qiongqiong Ren Wenshuai Jiang Zhen Jin Shiqi Pan Xiuli Yang Wu Ren |
| author_sort | Xuming Sun |
| collection | DOAJ |
| description | Glucose is the main source of energy in cellular metabolism and is essential for normal cellular function and growth. Abnormal glucose levels can lead to significant health issues, highlighting the importance of developing efficient, accessible, and precise glucose detection platform. Here, the Ti3C2Tx@Pt nanocomposites were developed with uniformly dispersed Pt nanoparticles using a simple self-reduction method, effectively addressing the tendency of pure metal nanoparticles to aggregate. The Ti3C2Tx@Pt nanocomposite demonstrated excellent peroxidase like activity and electrocatalytic property, enabling the development of a dual-mode detection platform for glucose that integrated both colorimetric and electrochemical sensing. The colorimetric biosensor demonstrated a linear detection range of 0.5–10 mM with a limit of detection (LOD) 1.37 μM, while the electrochemical biosensor exhibited a linear range of 0.01–11.7 mM with the detection limit of 7.4 μM. This dual-mode platform offered a simple, sensitive, and visualized approach for glucose detection, with broad potential for application in biomedical and clinical diagnostics. |
| format | Article |
| id | doaj-art-3e5e330edd2542ffa586ed6c9b1e92b3 |
| institution | DOAJ |
| issn | 2214-1804 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj-art-3e5e330edd2542ffa586ed6c9b1e92b32025-08-20T02:39:33ZengElsevierSensing and Bio-Sensing Research2214-18042025-06-014810080010.1016/j.sbsr.2025.100800Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detectionXuming Sun0Mingyan Zhang1Jinlong Chang2Linyan Xie3Qiongqiong Ren4Wenshuai Jiang5Zhen Jin6Shiqi Pan7Xiuli Yang8Wu Ren9School of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR China; Corresponding authors.School of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR ChinaSchool of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR ChinaSchool of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR ChinaSchool of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR ChinaSchool of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR ChinaSchool of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR ChinaSchool of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR ChinaThe Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, PR China; Corresponding authors.School of Medical Engineering, Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang 453003, PR China; Corresponding authors.Glucose is the main source of energy in cellular metabolism and is essential for normal cellular function and growth. Abnormal glucose levels can lead to significant health issues, highlighting the importance of developing efficient, accessible, and precise glucose detection platform. Here, the Ti3C2Tx@Pt nanocomposites were developed with uniformly dispersed Pt nanoparticles using a simple self-reduction method, effectively addressing the tendency of pure metal nanoparticles to aggregate. The Ti3C2Tx@Pt nanocomposite demonstrated excellent peroxidase like activity and electrocatalytic property, enabling the development of a dual-mode detection platform for glucose that integrated both colorimetric and electrochemical sensing. The colorimetric biosensor demonstrated a linear detection range of 0.5–10 mM with a limit of detection (LOD) 1.37 μM, while the electrochemical biosensor exhibited a linear range of 0.01–11.7 mM with the detection limit of 7.4 μM. This dual-mode platform offered a simple, sensitive, and visualized approach for glucose detection, with broad potential for application in biomedical and clinical diagnostics.http://www.sciencedirect.com/science/article/pii/S2214180425000662Glucose detectionTi3C2Tx@Pt nanocompositesDual-mode platformColorimetric detectionElectrochemical detection |
| spellingShingle | Xuming Sun Mingyan Zhang Jinlong Chang Linyan Xie Qiongqiong Ren Wenshuai Jiang Zhen Jin Shiqi Pan Xiuli Yang Wu Ren Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection Sensing and Bio-Sensing Research Glucose detection Ti3C2Tx@Pt nanocomposites Dual-mode platform Colorimetric detection Electrochemical detection |
| title | Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection |
| title_full | Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection |
| title_fullStr | Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection |
| title_full_unstemmed | Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection |
| title_short | Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection |
| title_sort | ti3c2tx pt nanocomposite based colorimetric and electrochemical dual mode platform for glucose detection |
| topic | Glucose detection Ti3C2Tx@Pt nanocomposites Dual-mode platform Colorimetric detection Electrochemical detection |
| url | http://www.sciencedirect.com/science/article/pii/S2214180425000662 |
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