Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma

Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma

Abstract Background We previously identified an oncogenic role for the transcription factor HNF1A in pancreatic ductal adenocarcinoma (PDAC). However, the role of HNF1A in the metastatic progression of PDAC remains unknown and targeting modalities for HNF1A-dependent phenotypes have yet to be identi...

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Main Authors: Katherine J. Crawford, Kennedy S. Humphrey, Eduardo Cortes, Jianxin Wang, Vishnu Kumarasamy, Yin Wan, Mark D. Long, Michael E. Feigin, Agnieszka K. Witkiewicz, Karen M. Mann, Erik S. Knudsen, Ethan V. Abel
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Cancer
Subjects:
PDAC
Pancreatic ductal adenocarcinoma
HNF1A
FGFR4
Metastasis
FGFR4 inhibitors
Online Access:https://doi.org/10.1186/s12943-025-02408-5
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