Genome-Wide Association Study of Immune Indices in Yaks
The yak is a vital livestock resource on the Qinghai–Tibet Plateau, renowned for its strong disease resistance and high-quality meat. However, various diseases pose significant threats to its health and lead to substantial economic losses. Current feeding management practices, along with available d...
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MDPI AG
2025-07-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/15/14/2114 |
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| author | Daoning Yu Xiaoming Ma Chun Huang Tong Wang Mengfan Zhang Fen Feng Xiaoyun Wu Yongfu La Xian Guo Ping Yan Derong Zhang Chunnian Liang |
| author_facet | Daoning Yu Xiaoming Ma Chun Huang Tong Wang Mengfan Zhang Fen Feng Xiaoyun Wu Yongfu La Xian Guo Ping Yan Derong Zhang Chunnian Liang |
| author_sort | Daoning Yu |
| collection | DOAJ |
| description | The yak is a vital livestock resource on the Qinghai–Tibet Plateau, renowned for its strong disease resistance and high-quality meat. However, various diseases pose significant threats to its health and lead to substantial economic losses. Current feeding management practices, along with available drugs and vaccines, have demonstrated limited effectiveness in preventing and controlling infectious diseases. Additionally, challenges such as drug resistance and the safety of animal products persist. Therefore, enhancing the disease-resistant breeding capacity of yaks is crucial. In this study, we examined 192 yaks by measuring the concentrations of 10 immune indicators in serum by using the ELISA method and conducting whole-genome resequencing, which identified 19,182,942 SNP loci. Through genome-wide association analysis, we detected 323 significant SNPs located near or within 125 candidate genes, most of which are associated with disease and significantly enriched in the TGF-β signaling pathway. Overall, our study identified a series of novel variants and candidate genes associated with disease resistance traits in yaks, providing important information for the molecular breeding of disease resistance in yaks. These results not only contribute to a deeper understanding of the function of disease resistance genes in yaks but also hold great potential for accelerating precision disease resistance breeding in yaks. |
| format | Article |
| id | doaj-art-3e5af956c7ba4089933cdd4bd8eac1d3 |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-3e5af956c7ba4089933cdd4bd8eac1d32025-08-20T03:36:15ZengMDPI AGAnimals2076-26152025-07-011514211410.3390/ani15142114Genome-Wide Association Study of Immune Indices in YaksDaoning Yu0Xiaoming Ma1Chun Huang2Tong Wang3Mengfan Zhang4Fen Feng5Xiaoyun Wu6Yongfu La7Xian Guo8Ping Yan9Derong Zhang10Chunnian Liang11Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaCollege of Life Sciences and Engineering, Northwest Minzu University, Lanzhou 730106, ChinaKey Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou 730050, ChinaThe yak is a vital livestock resource on the Qinghai–Tibet Plateau, renowned for its strong disease resistance and high-quality meat. However, various diseases pose significant threats to its health and lead to substantial economic losses. Current feeding management practices, along with available drugs and vaccines, have demonstrated limited effectiveness in preventing and controlling infectious diseases. Additionally, challenges such as drug resistance and the safety of animal products persist. Therefore, enhancing the disease-resistant breeding capacity of yaks is crucial. In this study, we examined 192 yaks by measuring the concentrations of 10 immune indicators in serum by using the ELISA method and conducting whole-genome resequencing, which identified 19,182,942 SNP loci. Through genome-wide association analysis, we detected 323 significant SNPs located near or within 125 candidate genes, most of which are associated with disease and significantly enriched in the TGF-β signaling pathway. Overall, our study identified a series of novel variants and candidate genes associated with disease resistance traits in yaks, providing important information for the molecular breeding of disease resistance in yaks. These results not only contribute to a deeper understanding of the function of disease resistance genes in yaks but also hold great potential for accelerating precision disease resistance breeding in yaks.https://www.mdpi.com/2076-2615/15/14/2114yakimmune indicesresequencingGWASSNP |
| spellingShingle | Daoning Yu Xiaoming Ma Chun Huang Tong Wang Mengfan Zhang Fen Feng Xiaoyun Wu Yongfu La Xian Guo Ping Yan Derong Zhang Chunnian Liang Genome-Wide Association Study of Immune Indices in Yaks Animals yak immune indices resequencing GWAS SNP |
| title | Genome-Wide Association Study of Immune Indices in Yaks |
| title_full | Genome-Wide Association Study of Immune Indices in Yaks |
| title_fullStr | Genome-Wide Association Study of Immune Indices in Yaks |
| title_full_unstemmed | Genome-Wide Association Study of Immune Indices in Yaks |
| title_short | Genome-Wide Association Study of Immune Indices in Yaks |
| title_sort | genome wide association study of immune indices in yaks |
| topic | yak immune indices resequencing GWAS SNP |
| url | https://www.mdpi.com/2076-2615/15/14/2114 |
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