Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center study
Objective. The best results in glioblastoma (GBM) are obtained through aggressive treatment comprising maximally radical but safe resection followed by chemoradiotherapy. However, certain patients will undergo only stereotactic biopsy. This paper aims to evaluate life expectancy in GBM patients who...
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2024-11-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202404-0011_life-expectancy-in-glioblastoma-patients-who-had-undergone-stereotactic-biopsy-a-retrospective-single-center-s.php |
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| author | Matej Halaj Ondrej Kalita Lucie Tuckova Lumir Hrabalek Martin Dolezel Jana Vrbkova |
| author_facet | Matej Halaj Ondrej Kalita Lucie Tuckova Lumir Hrabalek Martin Dolezel Jana Vrbkova |
| author_sort | Matej Halaj |
| collection | DOAJ |
| description | Objective. The best results in glioblastoma (GBM) are obtained through aggressive treatment comprising maximally radical but safe resection followed by chemoradiotherapy. However, certain patients will undergo only stereotactic biopsy. This paper aims to evaluate life expectancy in GBM patients who underwent only stereotactic biopsy, including the effect of subsequent oncological treatment. Patients and Methods. Patients with confirmed GBM histology who had undergone stereotactic biopsy between June 2006 and December 2016 were retrospectively selected. Each patient had received a CT scan, followed by an MRI scan with a contrast agent. None of the patients were amenable to microsurgical resection. Results. Of the 60 patients, 41 (69%) received no subsequent oncological treatment, while 14 (23%) underwent isolated radiotherapy. Mean survival time of all patients was 2.8 months. Those who received no additional treatment had an average survival time of 2.3 months; patients who received any type of oncological treatment was 3.7 months. Of these, those receiving radiotherapy alone had a mean survival of 3.1 months. Patients who received oncological treatment with the Stupp protocol had a survival time of 6.6 months. Conclusion. Diagnostic and surgical advances related to GBM treatment mean that radical resections can be performed even in eloquent brain areas. However, patients not indicated for resection will experience a major reduction in life expectancy. Patients who underwent stereotactic biopsy and received some form of oncological treatment experienced slightly increased overall survival relative to patients with a natural disease course. Patients with favorable clinical factors reacted better to treatment. |
| format | Article |
| id | doaj-art-3e5186d7b78144909ab9e68c5f2ec7b6 |
| institution | OA Journals |
| issn | 1213-8118 1804-7521 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj-art-3e5186d7b78144909ab9e68c5f2ec7b62025-08-20T02:22:45ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212024-11-01168434935310.5507/bp.2023.030bio-202404-0011Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center studyMatej Halaj0Ondrej Kalita1Lucie Tuckova2Lumir Hrabalek3Martin Dolezel4Jana Vrbkova5Department of Neurosurgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech RepublicDepartment of Neurosurgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech RepublicDepartment of Pathology and Laboratory of Molecular Pathology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech RepublicDepartment of Neurosurgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech RepublicDepartment of Oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech RepublicInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech RepublicObjective. The best results in glioblastoma (GBM) are obtained through aggressive treatment comprising maximally radical but safe resection followed by chemoradiotherapy. However, certain patients will undergo only stereotactic biopsy. This paper aims to evaluate life expectancy in GBM patients who underwent only stereotactic biopsy, including the effect of subsequent oncological treatment. Patients and Methods. Patients with confirmed GBM histology who had undergone stereotactic biopsy between June 2006 and December 2016 were retrospectively selected. Each patient had received a CT scan, followed by an MRI scan with a contrast agent. None of the patients were amenable to microsurgical resection. Results. Of the 60 patients, 41 (69%) received no subsequent oncological treatment, while 14 (23%) underwent isolated radiotherapy. Mean survival time of all patients was 2.8 months. Those who received no additional treatment had an average survival time of 2.3 months; patients who received any type of oncological treatment was 3.7 months. Of these, those receiving radiotherapy alone had a mean survival of 3.1 months. Patients who received oncological treatment with the Stupp protocol had a survival time of 6.6 months. Conclusion. Diagnostic and surgical advances related to GBM treatment mean that radical resections can be performed even in eloquent brain areas. However, patients not indicated for resection will experience a major reduction in life expectancy. Patients who underwent stereotactic biopsy and received some form of oncological treatment experienced slightly increased overall survival relative to patients with a natural disease course. Patients with favorable clinical factors reacted better to treatment.https://biomed.papers.upol.cz/artkey/bio-202404-0011_life-expectancy-in-glioblastoma-patients-who-had-undergone-stereotactic-biopsy-a-retrospective-single-center-s.phpglioblastomaneedle biopsypalliative care |
| spellingShingle | Matej Halaj Ondrej Kalita Lucie Tuckova Lumir Hrabalek Martin Dolezel Jana Vrbkova Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center study Biomedical Papers glioblastoma needle biopsy palliative care |
| title | Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center study |
| title_full | Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center study |
| title_fullStr | Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center study |
| title_full_unstemmed | Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center study |
| title_short | Life expectancy in glioblastoma patients who had undergone stereotactic biopsy: a retrospective single-center study |
| title_sort | life expectancy in glioblastoma patients who had undergone stereotactic biopsy a retrospective single center study |
| topic | glioblastoma needle biopsy palliative care |
| url | https://biomed.papers.upol.cz/artkey/bio-202404-0011_life-expectancy-in-glioblastoma-patients-who-had-undergone-stereotactic-biopsy-a-retrospective-single-center-s.php |
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