Pathogenesis of drug resistant epilepsy
Pharmacotherapy is the first-line treatment modality for epilepsy. However, in 20-40% of patients, epilepsy is resistant to pharmacotherapy. These numbers have not changed for decades despite the development and use of antiepileptic drugs with novel mechanisms of action. Drug-resistant epilepsy is n...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2019-04-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/460 |
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| author | S. M. Malyshev T. M. Alekseeva W. A. Khachatryan M. M. Galagudza |
| author_facet | S. M. Malyshev T. M. Alekseeva W. A. Khachatryan M. M. Galagudza |
| author_sort | S. M. Malyshev |
| collection | DOAJ |
| description | Pharmacotherapy is the first-line treatment modality for epilepsy. However, in 20-40% of patients, epilepsy is resistant to pharmacotherapy. These numbers have not changed for decades despite the development and use of antiepileptic drugs with novel mechanisms of action. Drug-resistant epilepsy is now considered a separate pathophysiologic and clinical entity. The existing hypotheses on its pathogenesis could be divided in two groups. Firstly, drug-resistance might be caused by an abnormal pharmacokinetics or pharmacodynamics of antiepileptic drugs as a result of congenital or acquired dysfunction of the transporter or receptor proteins. Secondly, it might be a consequence of inherent features of epilepsy per se, such as the so-called “intrinsic severity” or some disorder of the connectome. Taking into account the complexity of this phenomenon, the issue of drug resistance continues to remain in the focus of the current research efforts. |
| format | Article |
| id | doaj-art-3e516ade19504db7adfb6e05aa250974 |
| institution | Kabale University |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2019-04-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-3e516ade19504db7adfb6e05aa2509742025-08-20T03:39:32ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882019-04-01111798710.17749/2077-8333.2019.11.1.79-87436Pathogenesis of drug resistant epilepsyS. M. Malyshev0T. M. Alekseeva1W. A. Khachatryan2M. M. Galagudza3VA Almazov National Medical Research CenterVA Almazov National Medical Research CenterVA Almazov National Medical Research CenterVA Almazov National Medical Research CenterPharmacotherapy is the first-line treatment modality for epilepsy. However, in 20-40% of patients, epilepsy is resistant to pharmacotherapy. These numbers have not changed for decades despite the development and use of antiepileptic drugs with novel mechanisms of action. Drug-resistant epilepsy is now considered a separate pathophysiologic and clinical entity. The existing hypotheses on its pathogenesis could be divided in two groups. Firstly, drug-resistance might be caused by an abnormal pharmacokinetics or pharmacodynamics of antiepileptic drugs as a result of congenital or acquired dysfunction of the transporter or receptor proteins. Secondly, it might be a consequence of inherent features of epilepsy per se, such as the so-called “intrinsic severity” or some disorder of the connectome. Taking into account the complexity of this phenomenon, the issue of drug resistance continues to remain in the focus of the current research efforts.https://www.epilepsia.su/jour/article/view/460drug resistant epilepsyantiepileptic drugsconnectomicstranslational medicine |
| spellingShingle | S. M. Malyshev T. M. Alekseeva W. A. Khachatryan M. M. Galagudza Pathogenesis of drug resistant epilepsy Эпилепсия и пароксизмальные состояния drug resistant epilepsy antiepileptic drugs connectomics translational medicine |
| title | Pathogenesis of drug resistant epilepsy |
| title_full | Pathogenesis of drug resistant epilepsy |
| title_fullStr | Pathogenesis of drug resistant epilepsy |
| title_full_unstemmed | Pathogenesis of drug resistant epilepsy |
| title_short | Pathogenesis of drug resistant epilepsy |
| title_sort | pathogenesis of drug resistant epilepsy |
| topic | drug resistant epilepsy antiepileptic drugs connectomics translational medicine |
| url | https://www.epilepsia.su/jour/article/view/460 |
| work_keys_str_mv | AT smmalyshev pathogenesisofdrugresistantepilepsy AT tmalekseeva pathogenesisofdrugresistantepilepsy AT wakhachatryan pathogenesisofdrugresistantepilepsy AT mmgalagudza pathogenesisofdrugresistantepilepsy |