A conceptual exploration on the synergistic anti-tumor effects of high-order combination of OHSV2-DSTEFAP5/CD3, CAR-T cells, and immunotoxins in hepatocellular carcinoma

A conceptual exploration on the synergistic anti-tumor effects of high-order combination of OHSV2-DSTEFAP5/CD3, CAR-T cells, and immunotoxins in hepatocellular carcinoma

BackgroundAlthough the treatment landscape for advanced hepatocellular carcinoma (HCC) has seen significant advancements in the past decade with the introduction of immune checkpoint inhibitors and antiangiogenic drugs, progress has fallen short of expectations. Recently, a novel engineered oncolyti...

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Bibliographic Details
Main Authors: Shuang Dong, Xin Chen, Xiaoyu Li, Yang Wang, Qing Huang, Yuanxiang Li, Jing Jin, Xianmin Zhu, Yi Zhong, Qian Cai, Chang Xue, Fang Guo, Le Huang, Mingqian Feng, Binlei Liu, Sheng Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
oncolytic virus
CAR-T
immunotoxins
dual-specific T cell engagers
FAP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509087/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509087/full

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