Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma

Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma

Abstract Hepatoblastoma, the most aggressive childhood liver tumor, poses significant challenges due to limited knowledge of its pathogenesis, particularly in poorly differentiated advanced tumors where the prognosis is dismal. Single‐cell sequencing provides an in‐depth exploration at the single‐ce...

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Bibliographic Details
Main Authors: Miao Ding, Siwei Mao, Han Wu, Sijia Fang, Ni Zhen, Tianshu Chen, Jiabei Zhu, Xiaochen Tang, Xiaoyang Wang, Fenyong Sun, Guoqing Zhu, Qiuhui Pan, Ji Ma
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
cholesterol
collagen 1
fibroblast
IGF2
malignant hepatoblast‐like cells
SREBF2
Online Access:https://doi.org/10.1002/advs.202407671
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