Crotonylation modification and its role in diseases
Protein lysine crotonylation is a novel acylation modification discovered in 2011, which plays a key role in the regulation of various biological processes. Thousands of crotonylation sites have been identified in histone and non-histone proteins over the past decades. Crotonylation is conserved and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1492212/full |
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| _version_ | 1850192105582886912 |
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| author | Yi Guo Junqin Li Kaiming Zhang |
| author_facet | Yi Guo Junqin Li Kaiming Zhang |
| author_sort | Yi Guo |
| collection | DOAJ |
| description | Protein lysine crotonylation is a novel acylation modification discovered in 2011, which plays a key role in the regulation of various biological processes. Thousands of crotonylation sites have been identified in histone and non-histone proteins over the past decades. Crotonylation is conserved and is regulated by a series of enzymes including “writer”, “eraser”, and “reader”. In recent years, crotonylation has received extensive attention due to its breakthrough progress in reproduction, development and pathogenesis of diseases. Here we brief the crotonylation-related enzyme systems, biological functions, and diseases caused by abnormal crotonylation, which provide new ideas for developing disease intervention and treatment regimens. |
| format | Article |
| id | doaj-art-3e4c2a62e25f47c98acf796a7244eaa8 |
| institution | OA Journals |
| issn | 2296-889X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-3e4c2a62e25f47c98acf796a7244eaa82025-08-20T02:14:39ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2024-10-011110.3389/fmolb.2024.14922121492212Crotonylation modification and its role in diseasesYi GuoJunqin LiKaiming ZhangProtein lysine crotonylation is a novel acylation modification discovered in 2011, which plays a key role in the regulation of various biological processes. Thousands of crotonylation sites have been identified in histone and non-histone proteins over the past decades. Crotonylation is conserved and is regulated by a series of enzymes including “writer”, “eraser”, and “reader”. In recent years, crotonylation has received extensive attention due to its breakthrough progress in reproduction, development and pathogenesis of diseases. Here we brief the crotonylation-related enzyme systems, biological functions, and diseases caused by abnormal crotonylation, which provide new ideas for developing disease intervention and treatment regimens.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1492212/fullpost-translational modificationcrotonylationhistonenon-histone proteindisease |
| spellingShingle | Yi Guo Junqin Li Kaiming Zhang Crotonylation modification and its role in diseases Frontiers in Molecular Biosciences post-translational modification crotonylation histone non-histone protein disease |
| title | Crotonylation modification and its role in diseases |
| title_full | Crotonylation modification and its role in diseases |
| title_fullStr | Crotonylation modification and its role in diseases |
| title_full_unstemmed | Crotonylation modification and its role in diseases |
| title_short | Crotonylation modification and its role in diseases |
| title_sort | crotonylation modification and its role in diseases |
| topic | post-translational modification crotonylation histone non-histone protein disease |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1492212/full |
| work_keys_str_mv | AT yiguo crotonylationmodificationanditsroleindiseases AT junqinli crotonylationmodificationanditsroleindiseases AT kaimingzhang crotonylationmodificationanditsroleindiseases |