Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case report
Until recently, treatment options for patients with recurrent or metastatic endometrial cancer (EC) were limited. First-line treatment is usually based on carboplatin and paclitaxel and there was no standard second- line therapy following platinum failure. However, the introduction of immunotherapy...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioExcel Publishing Ltd
2025-06-01
|
| Series: | Drugs in Context |
| Subjects: | |
| Online Access: | https://www.drugsincontext.com/pseudoprogression-and-improvement-of-quality-of-life-in-a-patient-with-advanced-endometrial-cancer-treated-with-immunotherapy-a-case-report/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849426473131180032 |
|---|---|
| author | Valentina Tuninetti Roberta Danese Amedeo Calvo Marco Bellero Lavinia Bianco Valentina Ariu Maria Grazia Ruo Redda Paola Campisi Alessandra Bianco Giovanni De Rosa Massimo Petracchini Giorgio Valabrega |
| author_facet | Valentina Tuninetti Roberta Danese Amedeo Calvo Marco Bellero Lavinia Bianco Valentina Ariu Maria Grazia Ruo Redda Paola Campisi Alessandra Bianco Giovanni De Rosa Massimo Petracchini Giorgio Valabrega |
| author_sort | Valentina Tuninetti |
| collection | DOAJ |
| description | Until recently, treatment options for patients with recurrent or metastatic endometrial cancer (EC) were limited. First-line treatment is usually based on carboplatin and paclitaxel and there was no standard second- line therapy following platinum failure. However, the introduction of immunotherapy has expanded both first-line and later-line options for EC and made determination of mismatch repair status essential. We describe the case of a 56-year-old woman with deficient mismatch repair/microsatellite instability EC who did not respond to first-line treatment with carboplatin and paclitaxel but had a high response to subsequent immunotherapy with dostarlimab. There was initial pseudoprogression of one target lesion but marked improvement in quality of life.
This article is part of the New treatment options for advanced endometrial carcinoma Special Issue: https://www.drugsincontext.com/special_issues/new-treatment-options-for-advanced-endometrial-carcinoma |
| format | Article |
| id | doaj-art-3e4a8cfa748e4090946e0536392373fd |
| institution | Kabale University |
| issn | 1740-4398 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BioExcel Publishing Ltd |
| record_format | Article |
| series | Drugs in Context |
| spelling | doaj-art-3e4a8cfa748e4090946e0536392373fd2025-08-20T03:29:23ZengBioExcel Publishing LtdDrugs in Context1740-43982025-06-01141810.7573/dic.2025-4-7Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case reportValentina TuninettiRoberta DaneseAmedeo CalvoMarco BelleroLavinia BiancoValentina AriuMaria Grazia Ruo ReddaPaola CampisiAlessandra BiancoGiovanni De RosaMassimo PetracchiniGiorgio ValabregaUntil recently, treatment options for patients with recurrent or metastatic endometrial cancer (EC) were limited. First-line treatment is usually based on carboplatin and paclitaxel and there was no standard second- line therapy following platinum failure. However, the introduction of immunotherapy has expanded both first-line and later-line options for EC and made determination of mismatch repair status essential. We describe the case of a 56-year-old woman with deficient mismatch repair/microsatellite instability EC who did not respond to first-line treatment with carboplatin and paclitaxel but had a high response to subsequent immunotherapy with dostarlimab. There was initial pseudoprogression of one target lesion but marked improvement in quality of life. This article is part of the New treatment options for advanced endometrial carcinoma Special Issue: https://www.drugsincontext.com/special_issues/new-treatment-options-for-advanced-endometrial-carcinomahttps://www.drugsincontext.com/pseudoprogression-and-improvement-of-quality-of-life-in-a-patient-with-advanced-endometrial-cancer-treated-with-immunotherapy-a-case-report/dostarlimabendometrial cancerimmunotherapyquality of lifepseudoprogression |
| spellingShingle | Valentina Tuninetti Roberta Danese Amedeo Calvo Marco Bellero Lavinia Bianco Valentina Ariu Maria Grazia Ruo Redda Paola Campisi Alessandra Bianco Giovanni De Rosa Massimo Petracchini Giorgio Valabrega Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case report Drugs in Context dostarlimab endometrial cancer immunotherapy quality of life pseudoprogression |
| title | Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case report |
| title_full | Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case report |
| title_fullStr | Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case report |
| title_full_unstemmed | Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case report |
| title_short | Pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy: a case report |
| title_sort | pseudoprogression and improvement of quality of life in a patient with advanced endometrial cancer treated with immunotherapy a case report |
| topic | dostarlimab endometrial cancer immunotherapy quality of life pseudoprogression |
| url | https://www.drugsincontext.com/pseudoprogression-and-improvement-of-quality-of-life-in-a-patient-with-advanced-endometrial-cancer-treated-with-immunotherapy-a-case-report/ |
| work_keys_str_mv | AT valentinatuninetti pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT robertadanese pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT amedeocalvo pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT marcobellero pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT laviniabianco pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT valentinaariu pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT mariagraziaruoredda pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT paolacampisi pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT alessandrabianco pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT giovanniderosa pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT massimopetracchini pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport AT giorgiovalabrega pseudoprogressionandimprovementofqualityoflifeinapatientwithadvancedendometrialcancertreatedwithimmunotherapyacasereport |