Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment
The aim of this study is to review all the published clinical trials on autologous bone marrow mesenchymal stem cells (BM-MSCs) in the repair of cartilage lesions of the knee. We performed a comprehensive search in three electronic databases: PubMed, Medline via Ovid, and Web of Science. A systemati...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/3826054 |
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| author | Mohamed E. Awad Khaled A. Hussein Inas Helwa Mohamed F. Abdelsamid Alexandra Aguilar-Perez Ibrahim Mohsen Monte Hunter Mark W. Hamrick Carlos M. Isales Mohammed Elsalanty William D. Hill Sadanand Fulzele |
| author_facet | Mohamed E. Awad Khaled A. Hussein Inas Helwa Mohamed F. Abdelsamid Alexandra Aguilar-Perez Ibrahim Mohsen Monte Hunter Mark W. Hamrick Carlos M. Isales Mohammed Elsalanty William D. Hill Sadanand Fulzele |
| author_sort | Mohamed E. Awad |
| collection | DOAJ |
| description | The aim of this study is to review all the published clinical trials on autologous bone marrow mesenchymal stem cells (BM-MSCs) in the repair of cartilage lesions of the knee. We performed a comprehensive search in three electronic databases: PubMed, Medline via Ovid, and Web of Science. A systematic review was conducted according to the guidelines of PRISMA protocol and the Cochrane Handbook for Systematic Reviews of Interventions. The modified Coleman methodology score was used to assess the quality of the included studies. Meta-analysis was conducted to estimate the effect size for Pain and function change after receiving BM-MSCs. Thirty-three studies—including 724 patients of mean age 44.2 years—were eligible. 50.7% of the included patients received cultured BM-MSCs for knee cartilage repair. There was improvement in the MINORS quality score over time with a positive correlation with the publication year. Meta-analysis indicated better improvement and statistical significance in the Visual Analog Scale for Pain, IKDC Function, Tegner Activity Scale, and Lysholm Knee Score after administration of noncultured BM-MSCs when compared to evaluation before the treatment. Meanwhile, there was a clear methodological defect in most studies with an average modified Coleman methodology score (MCMS) of 55. BM-MSCs revealed a clinically relevant improvement in pain, function, and histological regeneration. |
| format | Article |
| id | doaj-art-3e4a8731dee843508abdae0e9e599c56 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-3e4a8731dee843508abdae0e9e599c562025-02-03T06:10:51ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/38260543826054Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality AssessmentMohamed E. Awad0Khaled A. Hussein1Inas Helwa2Mohamed F. Abdelsamid3Alexandra Aguilar-Perez4Ibrahim Mohsen5Monte Hunter6Mark W. Hamrick7Carlos M. Isales8Mohammed Elsalanty9William D. Hill10Sadanand Fulzele11Micro-CT Core, Oral Biology Department-Augusta University, Augusta, GA, USAOral and Maxillofacial Surgery-Oral and Dental Research Division-National Research Centre, Cairo, EgyptFaculty of Oral and Dental Medicine, Misr International University, Cairo, EgyptDepartment of Surgery, Mayo Clinic, Rochester, MN, USAAnatomy and Cell Biology Department-Indiana University School of Medicine, Indianapolis, IN, USADepartment of Orthopaedic Surgery, Fayoum University, Fayoum, EgyptDepartment of Orthopaedic Surgery, Augusta University, Augusta, GA, USADepartment of Orthopaedic Surgery, Augusta University, Augusta, GA, USADepartment of Orthopaedic Surgery, Augusta University, Augusta, GA, USAMicro-CT Core, Oral Biology Department-Augusta University, Augusta, GA, USADepartment of Orthopaedic Surgery, Augusta University, Augusta, GA, USADepartment of Orthopaedic Surgery, Augusta University, Augusta, GA, USAThe aim of this study is to review all the published clinical trials on autologous bone marrow mesenchymal stem cells (BM-MSCs) in the repair of cartilage lesions of the knee. We performed a comprehensive search in three electronic databases: PubMed, Medline via Ovid, and Web of Science. A systematic review was conducted according to the guidelines of PRISMA protocol and the Cochrane Handbook for Systematic Reviews of Interventions. The modified Coleman methodology score was used to assess the quality of the included studies. Meta-analysis was conducted to estimate the effect size for Pain and function change after receiving BM-MSCs. Thirty-three studies—including 724 patients of mean age 44.2 years—were eligible. 50.7% of the included patients received cultured BM-MSCs for knee cartilage repair. There was improvement in the MINORS quality score over time with a positive correlation with the publication year. Meta-analysis indicated better improvement and statistical significance in the Visual Analog Scale for Pain, IKDC Function, Tegner Activity Scale, and Lysholm Knee Score after administration of noncultured BM-MSCs when compared to evaluation before the treatment. Meanwhile, there was a clear methodological defect in most studies with an average modified Coleman methodology score (MCMS) of 55. BM-MSCs revealed a clinically relevant improvement in pain, function, and histological regeneration.http://dx.doi.org/10.1155/2019/3826054 |
| spellingShingle | Mohamed E. Awad Khaled A. Hussein Inas Helwa Mohamed F. Abdelsamid Alexandra Aguilar-Perez Ibrahim Mohsen Monte Hunter Mark W. Hamrick Carlos M. Isales Mohammed Elsalanty William D. Hill Sadanand Fulzele Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment Stem Cells International |
| title | Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment |
| title_full | Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment |
| title_fullStr | Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment |
| title_full_unstemmed | Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment |
| title_short | Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment |
| title_sort | meta analysis and evidence base for the efficacy of autologous bone marrow mesenchymal stem cells in knee cartilage repair methodological guidelines and quality assessment |
| url | http://dx.doi.org/10.1155/2019/3826054 |
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