The roles of lncMALAT1 in coronary artery disease regulation and therapeutic perspective: A systematic review
Summary: Coronary artery disease (CAD) accelerates cardiovascular morbidity and complications that threaten public health, necessitating a deeper understanding of its molecular regulators. This systematic review synthesizes evidence on long noncoding RNA (lncMALAT1), a critical indicator of CAD prog...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225012064 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Summary: Coronary artery disease (CAD) accelerates cardiovascular morbidity and complications that threaten public health, necessitating a deeper understanding of its molecular regulators. This systematic review synthesizes evidence on long noncoding RNA (lncMALAT1), a critical indicator of CAD progression through the regulation of autophagy, apoptosis, inflammation, and vascular remodeling. Analyzing 23 experimental studies (PRISMA-guided, PROSPERO-registered), we have identified key findings including MALAT1 modulation altered cardiac function, microstructure via miRNAs-mediated- pathways through in-vivo studies. In-vitro studies emphasized overexpression, knockdown, and combined both approaches. These studies investigated potential molecular targets and biological changes, while emphasizing miRNAs. Hypoxia or hypoxia/reoxygenation conditions were explored, revealing insights into apoptosis and cell viability. Innovations include mapping MALAT1’s interaction networks across both in-vivo and in-vitro experimental CAD contexts. The findings synthesized the role of lncMALAT1 in CAD, highlighting its potential as a biomarker and therapeutic target. Future research should focus on standardizing experimental designs and elucidating precise mechanisms. |
|---|---|
| ISSN: | 2589-0042 |