Explainable graph neural network based on metabolic brain imaging for differential diagnosis of parkinsonism

Explainable graph neural network based on metabolic brain imaging for differential diagnosis of parkinsonism

BackgroundAccurate differentiation of parkinsonian syndromes remains challenging due to overlapping clinical manifestations and subtle neuroimaging variations. This study introduces an explainable graph neural network (GNN) framework integrating a Regional Radiomics Similarity Network (R2SN) and Tra...

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Main Authors: Ronghua Ling, Xingxing Cen, Shaoyou Wu, Min Wang, Ying Zhang, Juanjuan Jiang, Jiaying Lu, Yingqian Liu, Chuantao Zuo, Jiehui Jiang, Yinghui Yang, Zhuangzhi Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
parkinsonism
glucose metabolism
graph neural network
brain imaging
classification
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1580910/full
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