Neurofilament light chain in serum of cancer patients with acute neurological complications
Aim: Neurofilament light chain (NfL) is a nonspecific sensitive biomarker of axonal damage.Methods: This case series identified cancer patients with neurological complications who had serum NfL measurements and paired these results to outcomes.Results: NfL serum levels were available in 15 patients...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | CNS Oncology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20450907.2024.2386233 |
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| author | Amulya Gottiparthy Keng Lam Suprateek Kundu Zixi Yang Ivo Tremont-Lukats Sudhakar Tummala |
| author_facet | Amulya Gottiparthy Keng Lam Suprateek Kundu Zixi Yang Ivo Tremont-Lukats Sudhakar Tummala |
| author_sort | Amulya Gottiparthy |
| collection | DOAJ |
| description | Aim: Neurofilament light chain (NfL) is a nonspecific sensitive biomarker of axonal damage.Methods: This case series identified cancer patients with neurological complications who had serum NfL measurements and paired these results to outcomes.Results: NfL serum levels were available in 15 patients with hematological malignancies or solid tumors. The neurological complications studied were immune effector cell–associated neurotoxicity syndrome, immune checkpoint inhibitor–related encephalopathy, anoxic brain injury, Guillain-Barre syndrome, hemophagocytic lymphohistiocytosis, transverse myelitis, paraneoplastic syndrome, central nervous system demyelinating disorder and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. All patients but one with serum NfL >900 pg/ml died during hospitalization.Conclusion: Serum NfL levels consistently corresponded to death, disease severity or recovery in this series. |
| format | Article |
| id | doaj-art-3e438a3cd4284e5cafa6ba00ee389bb6 |
| institution | OA Journals |
| issn | 2045-0907 2045-0915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CNS Oncology |
| spelling | doaj-art-3e438a3cd4284e5cafa6ba00ee389bb62025-08-20T02:07:09ZengTaylor & Francis GroupCNS Oncology2045-09072045-09152024-12-0113110.1080/20450907.2024.2386233Neurofilament light chain in serum of cancer patients with acute neurological complicationsAmulya Gottiparthy0Keng Lam1Suprateek Kundu2Zixi Yang3Ivo Tremont-Lukats4Sudhakar Tummala5Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, TX 77030, USADepartment of Neuro-Oncology, Division of Cancer Medicine, Unit 431, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Biostatistics, Unit 1411, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Biostatistics, Unit 1411, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAKenneth R Peak Brain & Pituitary Tumor Center, Houston Methodist Hospital, Houston, TX 77030, USADepartment of Neuro-Oncology, Division of Cancer Medicine, Unit 431, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAAim: Neurofilament light chain (NfL) is a nonspecific sensitive biomarker of axonal damage.Methods: This case series identified cancer patients with neurological complications who had serum NfL measurements and paired these results to outcomes.Results: NfL serum levels were available in 15 patients with hematological malignancies or solid tumors. The neurological complications studied were immune effector cell–associated neurotoxicity syndrome, immune checkpoint inhibitor–related encephalopathy, anoxic brain injury, Guillain-Barre syndrome, hemophagocytic lymphohistiocytosis, transverse myelitis, paraneoplastic syndrome, central nervous system demyelinating disorder and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. All patients but one with serum NfL >900 pg/ml died during hospitalization.Conclusion: Serum NfL levels consistently corresponded to death, disease severity or recovery in this series.https://www.tandfonline.com/doi/10.1080/20450907.2024.2386233cancercentral nervous systemNeurofilament light chainneurotoxicityperipheral nervous system |
| spellingShingle | Amulya Gottiparthy Keng Lam Suprateek Kundu Zixi Yang Ivo Tremont-Lukats Sudhakar Tummala Neurofilament light chain in serum of cancer patients with acute neurological complications CNS Oncology cancer central nervous system Neurofilament light chain neurotoxicity peripheral nervous system |
| title | Neurofilament light chain in serum of cancer patients with acute neurological complications |
| title_full | Neurofilament light chain in serum of cancer patients with acute neurological complications |
| title_fullStr | Neurofilament light chain in serum of cancer patients with acute neurological complications |
| title_full_unstemmed | Neurofilament light chain in serum of cancer patients with acute neurological complications |
| title_short | Neurofilament light chain in serum of cancer patients with acute neurological complications |
| title_sort | neurofilament light chain in serum of cancer patients with acute neurological complications |
| topic | cancer central nervous system Neurofilament light chain neurotoxicity peripheral nervous system |
| url | https://www.tandfonline.com/doi/10.1080/20450907.2024.2386233 |
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