MicroRNAs in the Neural Retina
The health and function of the visual system rely on a collaborative interaction between diverse classes of molecular regulators. One of these classes consists of transcription factors, which are known to bind to DNA and control the transcription activities of their target genes. For a long time, it...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2014/165897 |
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| _version_ | 1832558921982672896 |
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| author | Kalina Andreeva Nigel G. F. Cooper |
| author_facet | Kalina Andreeva Nigel G. F. Cooper |
| author_sort | Kalina Andreeva |
| collection | DOAJ |
| description | The health and function of the visual system rely on a collaborative interaction between diverse classes of molecular regulators. One of these classes consists of transcription factors, which are known to bind to DNA and control the transcription activities of their target genes. For a long time, it was thought that the transcription factors were the only regulators of gene expression. More recently, however, a novel class of regulators emerged. This class consists of a large number of small noncoding endogenous RNAs, namely, miRNAs. The miRNAs compose an essential component of posttranscriptional gene regulation, since they ultimately control the fate of gene transcripts. The retina, as a part of the central nervous system, is a well-established model for unraveling the molecular mechanisms underlying neuronal and glial functions. Numerous recent efforts have been made towards identification of miRNAs and their inferred roles in the visual pathway. In this review, we summarize the current state of our knowledge regarding the expression and function of miRNA in the neural retina and we discuss their potential uses as biomarkers for some retinal disorders. |
| format | Article |
| id | doaj-art-3e35e2786f1a4dccbd98d8998381a22f |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-3e35e2786f1a4dccbd98d8998381a22f2025-02-03T01:31:11ZengWileyInternational Journal of Genomics2314-436X2314-43782014-01-01201410.1155/2014/165897165897MicroRNAs in the Neural RetinaKalina Andreeva0Nigel G. F. Cooper1Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, 500 S. Preston Street, Louisville, KY 40292, USADepartment of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, 500 S. Preston Street, Louisville, KY 40292, USAThe health and function of the visual system rely on a collaborative interaction between diverse classes of molecular regulators. One of these classes consists of transcription factors, which are known to bind to DNA and control the transcription activities of their target genes. For a long time, it was thought that the transcription factors were the only regulators of gene expression. More recently, however, a novel class of regulators emerged. This class consists of a large number of small noncoding endogenous RNAs, namely, miRNAs. The miRNAs compose an essential component of posttranscriptional gene regulation, since they ultimately control the fate of gene transcripts. The retina, as a part of the central nervous system, is a well-established model for unraveling the molecular mechanisms underlying neuronal and glial functions. Numerous recent efforts have been made towards identification of miRNAs and their inferred roles in the visual pathway. In this review, we summarize the current state of our knowledge regarding the expression and function of miRNA in the neural retina and we discuss their potential uses as biomarkers for some retinal disorders.http://dx.doi.org/10.1155/2014/165897 |
| spellingShingle | Kalina Andreeva Nigel G. F. Cooper MicroRNAs in the Neural Retina International Journal of Genomics |
| title | MicroRNAs in the Neural Retina |
| title_full | MicroRNAs in the Neural Retina |
| title_fullStr | MicroRNAs in the Neural Retina |
| title_full_unstemmed | MicroRNAs in the Neural Retina |
| title_short | MicroRNAs in the Neural Retina |
| title_sort | micrornas in the neural retina |
| url | http://dx.doi.org/10.1155/2014/165897 |
| work_keys_str_mv | AT kalinaandreeva micrornasintheneuralretina AT nigelgfcooper micrornasintheneuralretina |