Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study
BackgroundThe triglyceride-glucose (TyG) index, a marker of insulin resistance, is linked to mortality in coronary artery disease, ischemic stroke, and heart failure. However, its association with functional disability remains unclear. This study explored the relationship between the TyG index, its...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1488124/full |
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| author | ZhiHong Wei GuanHua Nie GuanHua Nie GuanHua Nie Ji Li Jiali Zhang HaoLin Liu MinXuan Ma |
| author_facet | ZhiHong Wei GuanHua Nie GuanHua Nie GuanHua Nie Ji Li Jiali Zhang HaoLin Liu MinXuan Ma |
| author_sort | ZhiHong Wei |
| collection | DOAJ |
| description | BackgroundThe triglyceride-glucose (TyG) index, a marker of insulin resistance, is linked to mortality in coronary artery disease, ischemic stroke, and heart failure. However, its association with functional disability remains unclear. This study explored the relationship between the TyG index, its related parameters, and functional disability.MethodsData were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Functional disability was evaluated using the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales. Multivariate logistic regression and restricted cubic spline (RCS) models were used to assess the associations between TyG-related indices and the risk of functional disability. Subgroup analyses stratified by age, sex, smoking, drinking, and diabetes were performed. Additionally, propensity score matching (PSM) was applied to ensure the robustness of the findings.ResultsThe diagnosis rates were 1,510(16.32%) for ADL limited and 2,620(28.32%) for ADL-IADL limited. The TyG-related indices were significantly associated with ADL limited. [TyG index: Full adjusted OR = 1.23, 95%CI: 1.16–1.30, p < 0.001; TyG-BMI index: Full adjusted OR = 1.11, 95%CI: 1.05–1.18, p < 0.001; TyG-WC index: Full adjusted OR = 1.20, 95%CI: 1.13–1.27, p < 0.001; TyG-WHtR index: Full adjusted OR = 1.07, 95%CI: 1.01–1.14, p = 0.025]. The TyG-related indices were significantly associated with ADL-IADL limited. [TyG index: Full adjusted OR = 1.20, 95%CI: 1.14–1.26, p < 0.001; TyG-BMI index: Full adjusted OR = 1.13, 95%CI: 1.08–1.19, p < 0.001; TyG-WC index: Full adjusted OR = 1.14, 95%CI: 1.09–1.20, p < 0.001; TyG-WHtR index: Full adjusted OR = 1.13, 95%CI: 1.07–1.18, p < 0.001].ConclusionOur findings indicated a trend that, TyG-related indices significantly associated with increased risks of ADL limited and ADL-IADL limited populations. |
| format | Article |
| id | doaj-art-3e3095b4f24e466fa52f7d7ebaa10b41 |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-3e3095b4f24e466fa52f7d7ebaa10b412025-08-20T01:52:14ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-05-011710.3389/fnagi.2025.14881241488124Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal StudyZhiHong Wei0GuanHua Nie1GuanHua Nie2GuanHua Nie3Ji Li4Jiali Zhang5HaoLin Liu6MinXuan Ma71Hospital-Acquired Infection Control Department, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Nursing, Baoying People’s Hospital, Yangzhou, ChinaKunming Municipal Hospital of Traditional Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, ChinaInstitute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, GermanyDepartment of Nursing, Baoying People’s Hospital, Yangzhou, ChinaKunming Municipal Hospital of Traditional Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, ChinaNo.965 Hospital, Joint Logistics Support Force of Chinese PLA, Jilin, China1Hospital-Acquired Infection Control Department, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaBackgroundThe triglyceride-glucose (TyG) index, a marker of insulin resistance, is linked to mortality in coronary artery disease, ischemic stroke, and heart failure. However, its association with functional disability remains unclear. This study explored the relationship between the TyG index, its related parameters, and functional disability.MethodsData were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Functional disability was evaluated using the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales. Multivariate logistic regression and restricted cubic spline (RCS) models were used to assess the associations between TyG-related indices and the risk of functional disability. Subgroup analyses stratified by age, sex, smoking, drinking, and diabetes were performed. Additionally, propensity score matching (PSM) was applied to ensure the robustness of the findings.ResultsThe diagnosis rates were 1,510(16.32%) for ADL limited and 2,620(28.32%) for ADL-IADL limited. The TyG-related indices were significantly associated with ADL limited. [TyG index: Full adjusted OR = 1.23, 95%CI: 1.16–1.30, p < 0.001; TyG-BMI index: Full adjusted OR = 1.11, 95%CI: 1.05–1.18, p < 0.001; TyG-WC index: Full adjusted OR = 1.20, 95%CI: 1.13–1.27, p < 0.001; TyG-WHtR index: Full adjusted OR = 1.07, 95%CI: 1.01–1.14, p = 0.025]. The TyG-related indices were significantly associated with ADL-IADL limited. [TyG index: Full adjusted OR = 1.20, 95%CI: 1.14–1.26, p < 0.001; TyG-BMI index: Full adjusted OR = 1.13, 95%CI: 1.08–1.19, p < 0.001; TyG-WC index: Full adjusted OR = 1.14, 95%CI: 1.09–1.20, p < 0.001; TyG-WHtR index: Full adjusted OR = 1.13, 95%CI: 1.07–1.18, p < 0.001].ConclusionOur findings indicated a trend that, TyG-related indices significantly associated with increased risks of ADL limited and ADL-IADL limited populations.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1488124/fullADL limitedADL-IADL limitedTyGTyG-BMI indexTyG-WC indexTyG-WHtR index |
| spellingShingle | ZhiHong Wei GuanHua Nie GuanHua Nie GuanHua Nie Ji Li Jiali Zhang HaoLin Liu MinXuan Ma Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study Frontiers in Aging Neuroscience ADL limited ADL-IADL limited TyG TyG-BMI index TyG-WC index TyG-WHtR index |
| title | Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study |
| title_full | Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study |
| title_fullStr | Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study |
| title_full_unstemmed | Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study |
| title_short | Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study |
| title_sort | association of triglyceride glucose index and its related parameters with functional disability evidence from the china health and retirement longitudinal study |
| topic | ADL limited ADL-IADL limited TyG TyG-BMI index TyG-WC index TyG-WHtR index |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1488124/full |
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