Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies
Sepsis, a heterogeneous illness produced by a dysregulated host response to infection, remains a severe mortality risk. Recent discoveries in sepsis research have stressed phenotyping as a feasible strategy for tackling heterogeneity and enhancing therapy precision. Sepsis phenotyping has moved from...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1546474/full |
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| author | Xue Zhang Wei Zhang Huan Zhang Xuelian Liao Xuelian Liao |
| author_facet | Xue Zhang Wei Zhang Huan Zhang Xuelian Liao Xuelian Liao |
| author_sort | Xue Zhang |
| collection | DOAJ |
| description | Sepsis, a heterogeneous illness produced by a dysregulated host response to infection, remains a severe mortality risk. Recent discoveries in sepsis research have stressed phenotyping as a feasible strategy for tackling heterogeneity and enhancing therapy precision. Sepsis phenotyping has moved from traditional stratifications based on severity and prognosis to dynamic, phenotype-driven therapeutic options. This review covers recent progress in connecting sepsis subgroups to personalized treatments, with a focus on phenotype-based therapeutic predictions and decision-support systems. Despite ongoing challenges, such as standardizing phenotyping frameworks and incorporating findings into clinical practice, this topic has enormous promise. By investigating phenotypic variation in therapy responses, we hope to uncover new biomarkers and phenotype-driven therapeutic solutions, laying the groundwork for more effective therapies and, ultimately improving patient outcomes. |
| format | Article |
| id | doaj-art-3e2fc4dd91f64c329dd23f56ad7a883b |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3e2fc4dd91f64c329dd23f56ad7a883b2025-02-06T05:21:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15464741546474Sepsis subphenotypes: bridging the gaps in sepsis treatment strategiesXue Zhang0Wei Zhang1Huan Zhang2Xuelian Liao3Xuelian Liao4Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaInstitute of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan, ChinaSepsis, a heterogeneous illness produced by a dysregulated host response to infection, remains a severe mortality risk. Recent discoveries in sepsis research have stressed phenotyping as a feasible strategy for tackling heterogeneity and enhancing therapy precision. Sepsis phenotyping has moved from traditional stratifications based on severity and prognosis to dynamic, phenotype-driven therapeutic options. This review covers recent progress in connecting sepsis subgroups to personalized treatments, with a focus on phenotype-based therapeutic predictions and decision-support systems. Despite ongoing challenges, such as standardizing phenotyping frameworks and incorporating findings into clinical practice, this topic has enormous promise. By investigating phenotypic variation in therapy responses, we hope to uncover new biomarkers and phenotype-driven therapeutic solutions, laying the groundwork for more effective therapies and, ultimately improving patient outcomes.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1546474/fullsepsis heterogeneityphenotypingpersonalized therapyphenotype-driven treatmentbiomarkerstherapeutic target identification |
| spellingShingle | Xue Zhang Wei Zhang Huan Zhang Xuelian Liao Xuelian Liao Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies Frontiers in Immunology sepsis heterogeneity phenotyping personalized therapy phenotype-driven treatment biomarkers therapeutic target identification |
| title | Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies |
| title_full | Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies |
| title_fullStr | Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies |
| title_full_unstemmed | Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies |
| title_short | Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies |
| title_sort | sepsis subphenotypes bridging the gaps in sepsis treatment strategies |
| topic | sepsis heterogeneity phenotyping personalized therapy phenotype-driven treatment biomarkers therapeutic target identification |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1546474/full |
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