The association of non-exercise estimated cardiorespiratory fitness with hypertension and all-cause mortality in American and Chinese populations: evidence from NHANES and CHARLS
BackgroundThe Non-Exercise Estimated Cardiorespiratory Fitness (NEE-CRF) method has gained attention in recent years due to its simplicity and effectiveness. Hypertension and all-cause mortality are significant public health issues worldwide, highlighting the importance of exploring the association...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1497292/full |
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| author | Mo-Yao Tan Ping Zhang Si-Xuan Zhu Shan Wu Ming Gao |
| author_facet | Mo-Yao Tan Ping Zhang Si-Xuan Zhu Shan Wu Ming Gao |
| author_sort | Mo-Yao Tan |
| collection | DOAJ |
| description | BackgroundThe Non-Exercise Estimated Cardiorespiratory Fitness (NEE-CRF) method has gained attention in recent years due to its simplicity and effectiveness. Hypertension and all-cause mortality are significant public health issues worldwide, highlighting the importance of exploring the association between NEE-CRF and these two conditions.MethodsThe data from the National Health and Nutrition Examination Survey (NHANES) and the China Health and Retirement Longitudinal Study (CHARLS) were utilized to validate the association between NEE-CRF and hypertension as well as all-cause mortality. NEE-CRF was calculated using a sex-specific longitudinal non-exercise equation. To investigate the relationship between hypertension and all-cause mortality, multivariable regression analysis, generalized additive models, smooth curve fittings, and threshold effect analysis were employed. Logistic regression was used for hypertension analysis, while Cox proportional hazards regression was applied for all-cause mortality. Additionally, we conducted stratified analyses and interaction tests among different groups.ResultsIn the NHANES, after fully adjusting for covariates, each unit increase in NEE-CRF was associated with a 24% reduction in the risk of hypertension (OR: 0.76, 95% CI: 0.74–0.78) and a 12% reduction in the risk of all-cause mortality (HR: 0.88, 95% CI: 0.79–0.86). Subgroup analyses showed that the relationship between NEE-CRF and both hypertension and all-cause mortality remained negatively correlated across different subgroups. The negative association was also validated in the CHARLS.ConclusionsHigher NEE-CRF levels may reduce the risk of developing hypertension and all-cause mortality. |
| format | Article |
| id | doaj-art-3e2e64f89264486b9d526ff039050f5a |
| institution | DOAJ |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-04-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-3e2e64f89264486b9d526ff039050f5a2025-08-20T03:08:32ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-04-011210.3389/fcvm.2025.14972921497292The association of non-exercise estimated cardiorespiratory fitness with hypertension and all-cause mortality in American and Chinese populations: evidence from NHANES and CHARLSMo-Yao Tan0Ping Zhang1Si-Xuan Zhu2Shan Wu3Ming Gao4Department of Cardiology, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, ChinaDepartment of Cardiology, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, ChinaClinical Medical School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaClinical Medical School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Cardiology, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, ChinaBackgroundThe Non-Exercise Estimated Cardiorespiratory Fitness (NEE-CRF) method has gained attention in recent years due to its simplicity and effectiveness. Hypertension and all-cause mortality are significant public health issues worldwide, highlighting the importance of exploring the association between NEE-CRF and these two conditions.MethodsThe data from the National Health and Nutrition Examination Survey (NHANES) and the China Health and Retirement Longitudinal Study (CHARLS) were utilized to validate the association between NEE-CRF and hypertension as well as all-cause mortality. NEE-CRF was calculated using a sex-specific longitudinal non-exercise equation. To investigate the relationship between hypertension and all-cause mortality, multivariable regression analysis, generalized additive models, smooth curve fittings, and threshold effect analysis were employed. Logistic regression was used for hypertension analysis, while Cox proportional hazards regression was applied for all-cause mortality. Additionally, we conducted stratified analyses and interaction tests among different groups.ResultsIn the NHANES, after fully adjusting for covariates, each unit increase in NEE-CRF was associated with a 24% reduction in the risk of hypertension (OR: 0.76, 95% CI: 0.74–0.78) and a 12% reduction in the risk of all-cause mortality (HR: 0.88, 95% CI: 0.79–0.86). Subgroup analyses showed that the relationship between NEE-CRF and both hypertension and all-cause mortality remained negatively correlated across different subgroups. The negative association was also validated in the CHARLS.ConclusionsHigher NEE-CRF levels may reduce the risk of developing hypertension and all-cause mortality.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1497292/fullnon-exercise estimated cardiorespiratory fitnesshypertensionall-cause mortalityNHANESCHARLS |
| spellingShingle | Mo-Yao Tan Ping Zhang Si-Xuan Zhu Shan Wu Ming Gao The association of non-exercise estimated cardiorespiratory fitness with hypertension and all-cause mortality in American and Chinese populations: evidence from NHANES and CHARLS Frontiers in Cardiovascular Medicine non-exercise estimated cardiorespiratory fitness hypertension all-cause mortality NHANES CHARLS |
| title | The association of non-exercise estimated cardiorespiratory fitness with hypertension and all-cause mortality in American and Chinese populations: evidence from NHANES and CHARLS |
| title_full | The association of non-exercise estimated cardiorespiratory fitness with hypertension and all-cause mortality in American and Chinese populations: evidence from NHANES and CHARLS |
| title_fullStr | The association of non-exercise estimated cardiorespiratory fitness with hypertension and all-cause mortality in American and Chinese populations: evidence from NHANES and CHARLS |
| title_full_unstemmed | The association of non-exercise estimated cardiorespiratory fitness with hypertension and all-cause mortality in American and Chinese populations: evidence from NHANES and CHARLS |
| title_short | The association of non-exercise estimated cardiorespiratory fitness with hypertension and all-cause mortality in American and Chinese populations: evidence from NHANES and CHARLS |
| title_sort | association of non exercise estimated cardiorespiratory fitness with hypertension and all cause mortality in american and chinese populations evidence from nhanes and charls |
| topic | non-exercise estimated cardiorespiratory fitness hypertension all-cause mortality NHANES CHARLS |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1497292/full |
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