Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation

Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation

Abstract In the United States, impaired bone healing impacts ~600,000 patients annually. Bone morphogenetic protein 2 (rhBMP2) therapy is impeded by low bone quality and adverse effects. Here, mesenchymal stem cells, engineered to produce BMP2 and BMP2/7 containing extracellular vesicles (BMP2-EV an...

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Main Authors: Zeji Du, Skylar A. Rizzo, Tiffany L. Sarrafian, Monique S. Bagwell, Ryan C. Mahlberg, Ashley Amontree, Paige Schiebel, Dinah M. Tauferner, Zoe S. LeBrasseur, Tyra A. Witt, Mary Nagel, Kyla A. Boyd, Humberto De Vitto, Matthew L. Hillestad, Paul G. Stalboerger, Matthew T. Houdek, Rafael J. Sierra, Atta Behfar
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-025-00405-2
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