System biology-based assessment of the molecular mechanism of epigallocatechin gallate in Parkinson’s disease: via network pharmacology, in-silico evaluation & in-vitro studies

System biology-based assessment of the molecular mechanism of epigallocatechin gallate in Parkinson’s disease: via network pharmacology, in-silico evaluation & in-vitro studies

Abstract Epigallocatechin gallate (EGCG) compound (IMPHY000226) has the potential to modulate multiple molecular mechanisms involved in Parkinson’s disease. Multiple targets such as SIRT3, FOXO1, PRKAA1, PPARGC1A, and CREBBP directly regulate reactive oxygen species levels and oxidative stress, sugg...

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Bibliographic Details
Main Authors: Hannah Lalengzuali Fanai, Jagdish Chand, Sheikh F. Ahmad, Sabry M. Attia, Talha Bin Emran
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
SIRT3
FOXO1
Parkinson’s disease
Oxidative stress
Network pharmacology
Online Access:https://doi.org/10.1038/s41598-025-11592-9
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