Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment
Background. Oxidative stress is well documented in multiple sclerosis (MS) lesions, but its correspondence at peripheral level is still controversial. Objective. To evaluate peripheral oxidative stress markers in MS patients. Methods. We studied total blood levels of Coenzyme Q10 (CoQ10), oxidized...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/961863 |
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| author | Maira Gironi Bruno Borgiani Enrica Mariani Cristina Cursano Laura Mendozzi Rossella Cavarretta Marina Saresella Mario Clerici Giancarlo Comi Marco Rovaris Roberto Furlan |
| author_facet | Maira Gironi Bruno Borgiani Enrica Mariani Cristina Cursano Laura Mendozzi Rossella Cavarretta Marina Saresella Mario Clerici Giancarlo Comi Marco Rovaris Roberto Furlan |
| author_sort | Maira Gironi |
| collection | DOAJ |
| description | Background. Oxidative stress is well documented in multiple sclerosis (MS) lesions, but its correspondence at peripheral level is still controversial. Objective. To evaluate peripheral oxidative stress markers in MS patients. Methods. We studied total blood levels of Coenzyme Q10 (CoQ10), oxidized and reduced forms of glutathione, malondialdehyde, reactive oxygen species (ROS), anti-oxidized-low-density lipoproteins (anti-oxLDL) antibodies, and antioxidant power (PAO) in 87 patients with different MS clinical phenotypes and in 77 controls. Results. CoQ10 was lower whereas anti-oxLDL antibodies titer was higher in MS patients than in controls. The benign variant of MS displayed both higher CoQ10 and higher anti-oxLDL than other MS clinical variants. Female patients had lower CoQ10 and PAO and higher ROS than male patients. Differences were greater in younger patients with shorter disease duration. Surprisingly, there was no difference for these markers between treated and untreated patients. Conclusion. We found lower antioxidant agents and higher anti-oxLDL antibodies in MS, and the highest antibody titers occurred in the benign form. We suggest that natural anti-oxLDL antibodies can be protective against MS, saving blood brain barrier integrity. Our findings also suggest that milder MS is associated with a distinct oxidative stress pattern, which may provide a useful biomarker of disease prognosis. |
| format | Article |
| id | doaj-art-3e287fd7349342fabb7d4e614345dbb7 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3e287fd7349342fabb7d4e614345dbb72025-08-20T03:55:41ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/961863961863Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to TreatmentMaira Gironi0Bruno Borgiani1Enrica Mariani2Cristina Cursano3Laura Mendozzi4Rossella Cavarretta5Marina Saresella6Mario Clerici7Giancarlo Comi8Marco Rovaris9Roberto Furlan10INSPE, Ospedale San Raffaele, Via Olgettina 60, 20132 Milano, ItalyINSPE, Ospedale San Raffaele, Via Olgettina 60, 20132 Milano, ItalyCAM, Centro Polidiagnostico, Viale Elvezia Angolo Via Martiri delle Foibe 1, Monza, ItalyCAM, Centro Polidiagnostico, Viale Elvezia Angolo Via Martiri delle Foibe 1, Monza, ItalyFondazione IRCCS, S. Maria Nascente, Don Gnocchi, Via Alfonso Capecelatro 66, 20148 Milano, ItalyFondazione IRCCS, S. Maria Nascente, Don Gnocchi, Via Alfonso Capecelatro 66, 20148 Milano, ItalyFondazione IRCCS, S. Maria Nascente, Don Gnocchi, Via Alfonso Capecelatro 66, 20148 Milano, ItalyFondazione IRCCS, S. Maria Nascente, Don Gnocchi, Via Alfonso Capecelatro 66, 20148 Milano, ItalyINSPE, Ospedale San Raffaele, Via Olgettina 60, 20132 Milano, ItalyFondazione IRCCS, S. Maria Nascente, Don Gnocchi, Via Alfonso Capecelatro 66, 20148 Milano, ItalyINSPE, Ospedale San Raffaele, Via Olgettina 60, 20132 Milano, ItalyBackground. Oxidative stress is well documented in multiple sclerosis (MS) lesions, but its correspondence at peripheral level is still controversial. Objective. To evaluate peripheral oxidative stress markers in MS patients. Methods. We studied total blood levels of Coenzyme Q10 (CoQ10), oxidized and reduced forms of glutathione, malondialdehyde, reactive oxygen species (ROS), anti-oxidized-low-density lipoproteins (anti-oxLDL) antibodies, and antioxidant power (PAO) in 87 patients with different MS clinical phenotypes and in 77 controls. Results. CoQ10 was lower whereas anti-oxLDL antibodies titer was higher in MS patients than in controls. The benign variant of MS displayed both higher CoQ10 and higher anti-oxLDL than other MS clinical variants. Female patients had lower CoQ10 and PAO and higher ROS than male patients. Differences were greater in younger patients with shorter disease duration. Surprisingly, there was no difference for these markers between treated and untreated patients. Conclusion. We found lower antioxidant agents and higher anti-oxLDL antibodies in MS, and the highest antibody titers occurred in the benign form. We suggest that natural anti-oxLDL antibodies can be protective against MS, saving blood brain barrier integrity. Our findings also suggest that milder MS is associated with a distinct oxidative stress pattern, which may provide a useful biomarker of disease prognosis.http://dx.doi.org/10.1155/2014/961863 |
| spellingShingle | Maira Gironi Bruno Borgiani Enrica Mariani Cristina Cursano Laura Mendozzi Rossella Cavarretta Marina Saresella Mario Clerici Giancarlo Comi Marco Rovaris Roberto Furlan Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment Journal of Immunology Research |
| title | Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment |
| title_full | Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment |
| title_fullStr | Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment |
| title_full_unstemmed | Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment |
| title_short | Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment |
| title_sort | oxidative stress is differentially present in multiple sclerosis courses early evident and unrelated to treatment |
| url | http://dx.doi.org/10.1155/2014/961863 |
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