Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients
Background: This study aimed to explore the relationship between self-reported sleep disturbances (e.g., insomnia, REM sleep behavior disorder [RBD]) and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease (PD) patients. Methods: We conduc...
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Elsevier
2025-06-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525000919 |
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| author | Min Chen Gongbing Guo Shuangyu Liu Jingjing Cai Xueying Tong Xia Liu Yufei Zhang Yanhong Chen Jiangtao Huo |
| author_facet | Min Chen Gongbing Guo Shuangyu Liu Jingjing Cai Xueying Tong Xia Liu Yufei Zhang Yanhong Chen Jiangtao Huo |
| author_sort | Min Chen |
| collection | DOAJ |
| description | Background: This study aimed to explore the relationship between self-reported sleep disturbances (e.g., insomnia, REM sleep behavior disorder [RBD]) and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease (PD) patients. Methods: We conducted a cross-sectional study comparing 100 PD patients (observation group) with 100 age-matched controls. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and serum levels of amyloid-beta (Aβ1-42), α-synuclein, and inflammatory markers (CRP, TNF-α, IL-1β) were quantified. Results: PD patients exhibited significantly poorer sleep quality (PSQI total score: 2.11 ± 0.27 vs. 0.52 ± 0.02, P < 0.001), reduced parietal cortical thickness (2.68 ± 0.12 mm vs. 3.15 ± 0.18 mm, P = 0.003), and lower brainstem volume (2697.42 ± 147.05 mm3 vs. 3185.16 ± 255.41 mm3, P = 0.007) compared to controls. Biomarker profiling revealed elevated amyloid pathology in PD, with higher serum Aβ1-42 (median [IQR]: 1.98 [1.75–2.22] vs. 1.14 [1.10–1.19], P < 0.001) and α-synuclein (2.03 [1.85–2.22] vs. 1.06 [1.03–1.10], P < 0.001). Proinflammatory markers were markedly increased in PD, including CRP (9.30 [7.85–10.75] vs. 6.30 [5.60–7.10], P = 0.01), TNF-α (372.20 [329.85–414.55] vs. 184.50 [165.20–203.80], P < 0.001), and IL-1β (573.50 [497.15–649.85] vs. 115.40 [101.05–129.75], P < 0.001). Multivariate analysis identified cortical thinning, brainstem atrophy, and IL-1β elevation as independent predictors of sleep disturbances (P < 0.05). Conclusion: These findings highlight the interplay between neuroanatomical changes, amyloid pathology, and systemic inflammation in PD-related sleep dysfunction, suggesting potential therapeutic targets. |
| format | Article |
| id | doaj-art-3e263e2cd79e4808a33c47b00fb96f82 |
| institution | OA Journals |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-3e263e2cd79e4808a33c47b00fb96f822025-08-20T02:16:18ZengElsevierExperimental Gerontology1873-68152025-06-0120511276210.1016/j.exger.2025.112762Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patientsMin Chen0Gongbing Guo1Shuangyu Liu2Jingjing Cai3Xueying Tong4Xia Liu5Yufei Zhang6Yanhong Chen7Jiangtao Huo8Department of Geriatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Geriatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Geriatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of General Practitioner, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Geriatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaOut-patient Department, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Geriatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaChinese Medicine Rehabilitation Comprehensive Department, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China; Corresponding author.Department of Geriatrics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China; Correspondence to: J. Huo, Department of Geriatrics, Taihe Hospital, Hubei University of Medicine, 30 South Renmin Road, 442000 Shiyan, Hubei, China.Background: This study aimed to explore the relationship between self-reported sleep disturbances (e.g., insomnia, REM sleep behavior disorder [RBD]) and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease (PD) patients. Methods: We conducted a cross-sectional study comparing 100 PD patients (observation group) with 100 age-matched controls. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and serum levels of amyloid-beta (Aβ1-42), α-synuclein, and inflammatory markers (CRP, TNF-α, IL-1β) were quantified. Results: PD patients exhibited significantly poorer sleep quality (PSQI total score: 2.11 ± 0.27 vs. 0.52 ± 0.02, P < 0.001), reduced parietal cortical thickness (2.68 ± 0.12 mm vs. 3.15 ± 0.18 mm, P = 0.003), and lower brainstem volume (2697.42 ± 147.05 mm3 vs. 3185.16 ± 255.41 mm3, P = 0.007) compared to controls. Biomarker profiling revealed elevated amyloid pathology in PD, with higher serum Aβ1-42 (median [IQR]: 1.98 [1.75–2.22] vs. 1.14 [1.10–1.19], P < 0.001) and α-synuclein (2.03 [1.85–2.22] vs. 1.06 [1.03–1.10], P < 0.001). Proinflammatory markers were markedly increased in PD, including CRP (9.30 [7.85–10.75] vs. 6.30 [5.60–7.10], P = 0.01), TNF-α (372.20 [329.85–414.55] vs. 184.50 [165.20–203.80], P < 0.001), and IL-1β (573.50 [497.15–649.85] vs. 115.40 [101.05–129.75], P < 0.001). Multivariate analysis identified cortical thinning, brainstem atrophy, and IL-1β elevation as independent predictors of sleep disturbances (P < 0.05). Conclusion: These findings highlight the interplay between neuroanatomical changes, amyloid pathology, and systemic inflammation in PD-related sleep dysfunction, suggesting potential therapeutic targets.http://www.sciencedirect.com/science/article/pii/S0531556525000919Parkinson's diseaseSleep disturbancesCortical thicknessBrainstem volumeAmyloid-betaInflammation |
| spellingShingle | Min Chen Gongbing Guo Shuangyu Liu Jingjing Cai Xueying Tong Xia Liu Yufei Zhang Yanhong Chen Jiangtao Huo Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients Experimental Gerontology Parkinson's disease Sleep disturbances Cortical thickness Brainstem volume Amyloid-beta Inflammation |
| title | Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients |
| title_full | Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients |
| title_fullStr | Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients |
| title_full_unstemmed | Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients |
| title_short | Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients |
| title_sort | investigating the relationship between sleep disturbances and cortical thickness brainstem volume amyloid accumulation and inflammatory markers in parkinson s disease patients |
| topic | Parkinson's disease Sleep disturbances Cortical thickness Brainstem volume Amyloid-beta Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525000919 |
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