Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review
Abstract Background Complications arising from acute traumatic spinal cord injury (SCI) are routinely managed by various pharmacological interventions. Despite decades of clinical application, the potential impact on neurological recovery has been largely overlooked. This study aims to highlight com...
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Nature Portfolio
2024-10-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-024-00638-0 |
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| author | Lucie Bourguignon Louis P. Lukas Bethany R. Kondiles Bobo Tong Jaimie J. Lee Tomás Gomes Wolfram Tetzlaff John L. K. Kramer Matthias Walter Catherine R. Jutzeler |
| author_facet | Lucie Bourguignon Louis P. Lukas Bethany R. Kondiles Bobo Tong Jaimie J. Lee Tomás Gomes Wolfram Tetzlaff John L. K. Kramer Matthias Walter Catherine R. Jutzeler |
| author_sort | Lucie Bourguignon |
| collection | DOAJ |
| description | Abstract Background Complications arising from acute traumatic spinal cord injury (SCI) are routinely managed by various pharmacological interventions. Despite decades of clinical application, the potential impact on neurological recovery has been largely overlooked. This study aims to highlight commonly administered drugs with potential disease-modifying effects. Methods This systematic literature review included studies referenced in PubMed, Scopus and Web of Science from inception to March 31st, 2021, which assess disease-modifying properties on neurological and/or functional recovery of drugs routinely administered following spinal cord injury. Drug effects were classified as positive, negative, mixed, no effect, or not (statistically) reported. Risk of bias was assessed separately for animal, randomized clinical trials, and observational human studies. Results We analyzed 394 studies conducting 486 experiments that evaluated 144 unique or combinations of drugs. 195 of the 464 experiments conducted on animals (42%) and one study in humans demonstrate positive disease-modifying properties on neurological and/or functional outcomes. Methylprednisolone, melatonin, estradiol, and atorvastatin are the most common drugs associated with positive effects. Two studies on morphine and ethanol report negative effects on recovery. Conclusion Despite a large heterogeneity observed in study protocols, research from bed to bench and back to bedside provides an alternative approach to identify new candidate drugs in the context of SCI. Future research in human populations is warranted to determine if introducing drugs like melatonin, estradiol, or atorvastatin would contribute to enhancing neurological outcomes after acute SCI. |
| format | Article |
| id | doaj-art-3e23e9b729bd4430b06b33fec65d52be |
| institution | OA Journals |
| issn | 2730-664X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Medicine |
| spelling | doaj-art-3e23e9b729bd4430b06b33fec65d52be2025-08-20T02:11:47ZengNature PortfolioCommunications Medicine2730-664X2024-10-014111310.1038/s43856-024-00638-0Impact of commonly administered drugs on the progression of spinal cord injury: a systematic reviewLucie Bourguignon0Louis P. Lukas1Bethany R. Kondiles2Bobo Tong3Jaimie J. Lee4Tomás Gomes5Wolfram Tetzlaff6John L. K. Kramer7Matthias Walter8Catherine R. Jutzeler9Department of Health Sciences and Technology, ETH ZurichDepartment of Health Sciences and Technology, ETH ZurichInternational Collaboration on Repair Discoveries (ICORD), University of British ColumbiaInternational Collaboration on Repair Discoveries (ICORD), University of British ColumbiaInternational Collaboration on Repair Discoveries (ICORD), University of British ColumbiaDepartment of Biosystems Science and Engineering, ETH ZurichInternational Collaboration on Repair Discoveries (ICORD), University of British ColumbiaInternational Collaboration on Repair Discoveries (ICORD), University of British ColumbiaDepartment of Urology, University Hospital Basel, University of BaselDepartment of Health Sciences and Technology, ETH ZurichAbstract Background Complications arising from acute traumatic spinal cord injury (SCI) are routinely managed by various pharmacological interventions. Despite decades of clinical application, the potential impact on neurological recovery has been largely overlooked. This study aims to highlight commonly administered drugs with potential disease-modifying effects. Methods This systematic literature review included studies referenced in PubMed, Scopus and Web of Science from inception to March 31st, 2021, which assess disease-modifying properties on neurological and/or functional recovery of drugs routinely administered following spinal cord injury. Drug effects were classified as positive, negative, mixed, no effect, or not (statistically) reported. Risk of bias was assessed separately for animal, randomized clinical trials, and observational human studies. Results We analyzed 394 studies conducting 486 experiments that evaluated 144 unique or combinations of drugs. 195 of the 464 experiments conducted on animals (42%) and one study in humans demonstrate positive disease-modifying properties on neurological and/or functional outcomes. Methylprednisolone, melatonin, estradiol, and atorvastatin are the most common drugs associated with positive effects. Two studies on morphine and ethanol report negative effects on recovery. Conclusion Despite a large heterogeneity observed in study protocols, research from bed to bench and back to bedside provides an alternative approach to identify new candidate drugs in the context of SCI. Future research in human populations is warranted to determine if introducing drugs like melatonin, estradiol, or atorvastatin would contribute to enhancing neurological outcomes after acute SCI.https://doi.org/10.1038/s43856-024-00638-0 |
| spellingShingle | Lucie Bourguignon Louis P. Lukas Bethany R. Kondiles Bobo Tong Jaimie J. Lee Tomás Gomes Wolfram Tetzlaff John L. K. Kramer Matthias Walter Catherine R. Jutzeler Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review Communications Medicine |
| title | Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review |
| title_full | Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review |
| title_fullStr | Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review |
| title_full_unstemmed | Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review |
| title_short | Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review |
| title_sort | impact of commonly administered drugs on the progression of spinal cord injury a systematic review |
| url | https://doi.org/10.1038/s43856-024-00638-0 |
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