Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea
Background: Morphoea is a sclerosing disorder of skin and subcutaneous tissue. Paediatric morphoea shows increased prevalence of various auto-immune diseases, bone deformities, and systemic abnormalities. There is paucity of studies on various immunological, skeletal, and thyroid function abnormalit...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Dermatology |
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| Online Access: | https://journals.lww.com/10.4103/ijd.ijd_1081_23 |
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| author | Vibhu Mendiratta Anuja Yadav Amit K. Meena Suvarna Samudrala Ritu Singh Vishal Parmar |
| author_facet | Vibhu Mendiratta Anuja Yadav Amit K. Meena Suvarna Samudrala Ritu Singh Vishal Parmar |
| author_sort | Vibhu Mendiratta |
| collection | DOAJ |
| description | Background:
Morphoea is a sclerosing disorder of skin and subcutaneous tissue. Paediatric morphoea shows increased prevalence of various auto-immune diseases, bone deformities, and systemic abnormalities. There is paucity of studies on various immunological, skeletal, and thyroid function abnormalities in paediatric morphoea.
Aims and Objectives:
To describe immunological, skeletal, and thyroid function abnormalities present in paediatric morphoea patients.
Materials and Methods:
This cross-sectional study was conducted from January 2021 to March 2023 in the Dermatology outpatient department in a tertiary care hospital. All paediatric morphoea patients were included in this study. All were subjected to detailed history, clinical examination, and investigations including complete blood count, serum IgE, anti-nuclear antibody, thyroid function tests, anti-thyroid peroxidase antibodies, and radiological investigations.
Results:
A total of 42 children were recruited, out of which 61.90% were females and 38.09% were males. The majority were in the age group of 4–8 years. The most common type of morphoea was encoup de sabre. Anaemia was present in 14.28% patients. Serum IgE levels were raised in 33.33% patients. Thyroid stimulating hormone was raised in 11.9% patients. 33.33% had raised anti-thyroid peroxidase levels. Anti-nuclear antibody titres and rheumatoid factor were raised in 7.14% and 4.76% patients, respectively. Magnetic resonance imaging brain revealed abnormalities in three patients as hyper-intensities in subcortical white matter.
Conclusion:
Morphoea in children can be associated with varied immunological, osteoarticular, and neurological abnormalities. This study highlights the multi-system involvement in morphoea and the need for larger data and well-designed therapeutic trials for generating evidence-based treatment of this potentially disfiguring disease. |
| format | Article |
| id | doaj-art-3e2294b42e184eaf9e70657454a16abe |
| institution | OA Journals |
| issn | 0019-5154 1998-3611 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj-art-3e2294b42e184eaf9e70657454a16abe2025-08-20T02:37:05ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112025-01-01701505010.4103/ijd.ijd_1081_23Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric MorphoeaVibhu MendirattaAnuja YadavAmit K. MeenaSuvarna SamudralaRitu SinghVishal ParmarBackground: Morphoea is a sclerosing disorder of skin and subcutaneous tissue. Paediatric morphoea shows increased prevalence of various auto-immune diseases, bone deformities, and systemic abnormalities. There is paucity of studies on various immunological, skeletal, and thyroid function abnormalities in paediatric morphoea. Aims and Objectives: To describe immunological, skeletal, and thyroid function abnormalities present in paediatric morphoea patients. Materials and Methods: This cross-sectional study was conducted from January 2021 to March 2023 in the Dermatology outpatient department in a tertiary care hospital. All paediatric morphoea patients were included in this study. All were subjected to detailed history, clinical examination, and investigations including complete blood count, serum IgE, anti-nuclear antibody, thyroid function tests, anti-thyroid peroxidase antibodies, and radiological investigations. Results: A total of 42 children were recruited, out of which 61.90% were females and 38.09% were males. The majority were in the age group of 4–8 years. The most common type of morphoea was encoup de sabre. Anaemia was present in 14.28% patients. Serum IgE levels were raised in 33.33% patients. Thyroid stimulating hormone was raised in 11.9% patients. 33.33% had raised anti-thyroid peroxidase levels. Anti-nuclear antibody titres and rheumatoid factor were raised in 7.14% and 4.76% patients, respectively. Magnetic resonance imaging brain revealed abnormalities in three patients as hyper-intensities in subcortical white matter. Conclusion: Morphoea in children can be associated with varied immunological, osteoarticular, and neurological abnormalities. This study highlights the multi-system involvement in morphoea and the need for larger data and well-designed therapeutic trials for generating evidence-based treatment of this potentially disfiguring disease.https://journals.lww.com/10.4103/ijd.ijd_1081_23anti-nuclear antibodymorphoeaskeletal abnormalitythyroid function testtrauma |
| spellingShingle | Vibhu Mendiratta Anuja Yadav Amit K. Meena Suvarna Samudrala Ritu Singh Vishal Parmar Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea Indian Journal of Dermatology anti-nuclear antibody morphoea skeletal abnormality thyroid function test trauma |
| title | Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea |
| title_full | Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea |
| title_fullStr | Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea |
| title_full_unstemmed | Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea |
| title_short | Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea |
| title_sort | assessment of immunological skeletal and thyroid function abnormalities in paediatric morphoea |
| topic | anti-nuclear antibody morphoea skeletal abnormality thyroid function test trauma |
| url | https://journals.lww.com/10.4103/ijd.ijd_1081_23 |
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