Systemic Treatments for Noninfectious Vitreous Inflammation
Vitreous inflammation, or vitritis, may result from many causes, including both infectious and noninfectious, including rheumatologic and autoimmune processes. Vitritis is commonly vision threatening and has serious sequelae. Treatment is frequently challenging, but, today, there are multiple method...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/515312 |
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| _version_ | 1841524713821569024 |
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| author | Angela Jiang Jillian Wang Malav Joshi John Byron Christoforidis |
| author_facet | Angela Jiang Jillian Wang Malav Joshi John Byron Christoforidis |
| author_sort | Angela Jiang |
| collection | DOAJ |
| description | Vitreous inflammation, or vitritis, may result from many causes, including both infectious and noninfectious, including rheumatologic and autoimmune processes. Vitritis is commonly vision threatening and has serious sequelae. Treatment is frequently challenging, but, today, there are multiple methods of systemic treatment for vitritis. These categories include corticosteroids, antimetabolites, alkylating agents, T-cell inhibitors/calcineurin inhibitors, and biologic agents. These treatment categories were reviewed last year, but, even over the course of just a year, many therapies have made progress, as we have learned more about their indications and efficacy. We discuss here discoveries made over the past year on both existing and new drugs, as well as reviewing mechanisms of action, clinical dosages, specific conditions that are treated, adverse effects, and usual course of treatment for each class of therapy. |
| format | Article |
| id | doaj-art-3e2207e99dbd464fa5c72398356fadb1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3e2207e99dbd464fa5c72398356fadb12025-02-03T05:47:29ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/515312515312Systemic Treatments for Noninfectious Vitreous InflammationAngela Jiang0Jillian Wang1Malav Joshi2John Byron Christoforidis3Department of Ophthalmology, The Ohio State University Wexner Medical Center, 915 Olentangy River Road, Suite 5000, Columbus, OH 43212, USADepartment of Ophthalmology, The Ohio State University Wexner Medical Center, 915 Olentangy River Road, Suite 5000, Columbus, OH 43212, USADepartment of Ophthalmology, The University of Arizona Medical Center, 655 North Alvernon Way, Suite 108, Tucson, AZ 85711, USADepartment of Ophthalmology, The University of Arizona Medical Center, 655 North Alvernon Way, Suite 108, Tucson, AZ 85711, USAVitreous inflammation, or vitritis, may result from many causes, including both infectious and noninfectious, including rheumatologic and autoimmune processes. Vitritis is commonly vision threatening and has serious sequelae. Treatment is frequently challenging, but, today, there are multiple methods of systemic treatment for vitritis. These categories include corticosteroids, antimetabolites, alkylating agents, T-cell inhibitors/calcineurin inhibitors, and biologic agents. These treatment categories were reviewed last year, but, even over the course of just a year, many therapies have made progress, as we have learned more about their indications and efficacy. We discuss here discoveries made over the past year on both existing and new drugs, as well as reviewing mechanisms of action, clinical dosages, specific conditions that are treated, adverse effects, and usual course of treatment for each class of therapy.http://dx.doi.org/10.1155/2013/515312 |
| spellingShingle | Angela Jiang Jillian Wang Malav Joshi John Byron Christoforidis Systemic Treatments for Noninfectious Vitreous Inflammation Mediators of Inflammation |
| title | Systemic Treatments for Noninfectious Vitreous Inflammation |
| title_full | Systemic Treatments for Noninfectious Vitreous Inflammation |
| title_fullStr | Systemic Treatments for Noninfectious Vitreous Inflammation |
| title_full_unstemmed | Systemic Treatments for Noninfectious Vitreous Inflammation |
| title_short | Systemic Treatments for Noninfectious Vitreous Inflammation |
| title_sort | systemic treatments for noninfectious vitreous inflammation |
| url | http://dx.doi.org/10.1155/2013/515312 |
| work_keys_str_mv | AT angelajiang systemictreatmentsfornoninfectiousvitreousinflammation AT jillianwang systemictreatmentsfornoninfectiousvitreousinflammation AT malavjoshi systemictreatmentsfornoninfectiousvitreousinflammation AT johnbyronchristoforidis systemictreatmentsfornoninfectiousvitreousinflammation |