An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis
Purpose. To determine the clinical features, microbial profiles, treatment outcomes, and prognostic factors for endogenous bacterial endophthalmitis (EBE). Methods. The medical records of 27 eyes of 21 patients diagnosed with EBE for 11 years were reviewed. Collected data included age, site of infec...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/261310 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558515577683968 |
|---|---|
| author | Takashi Nishida Kyoko Ishida Yoshiaki Niwa Hideaki Kawakami Kiyofumi Mochizuki Kiyofumi Ohkusu |
| author_facet | Takashi Nishida Kyoko Ishida Yoshiaki Niwa Hideaki Kawakami Kiyofumi Mochizuki Kiyofumi Ohkusu |
| author_sort | Takashi Nishida |
| collection | DOAJ |
| description | Purpose. To determine the clinical features, microbial profiles, treatment outcomes, and prognostic factors for endogenous bacterial endophthalmitis (EBE). Methods. The medical records of 27 eyes of 21 patients diagnosed with EBE for 11 years were reviewed. Collected data included age, site of infection, visual acuities (VAs), microbial profiles, and treatment regimen. Results. The mean age was 68.5 years. Gram-positive organisms accounted for 76.2%, while gram-negative ones accounted for 19.0%. Staphylococcus aureus was the most common causative organism (52.3%) of which 72.7% was methicillin-resistant S. aureus. A final VA of ≥20/40 was achieved in 44% and 20/200 or better was in 64%. Eyes with initial VA of ≥20/200 (P = 0.003) and focal involvements (P = 0.011) had significantly better final VA. Initial VA (P = 0.001) and the interval between onset of ocular symptoms and intravitreal antibiotic injection (P = 0.097) were associated with final VA in eyes receiving intravitreal antibiotics. Conclusions. EBE is generally associated with poor visual outcome; however the prognosis may depend on initial VA, extent of ocular involvement, and an interval between onset of ocular symptoms and intravitreal antibiotic injection. Early diagnosis and early intravitreal injection supplement to systemic antibiotics might lead to a relatively good visual outcome. |
| format | Article |
| id | doaj-art-3e21eff459f04a3881bf0b8ac67178bd |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-3e21eff459f04a3881bf0b8ac67178bd2025-02-03T01:32:12ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/261310261310An Eleven-Year Retrospective Study of Endogenous Bacterial EndophthalmitisTakashi Nishida0Kyoko Ishida1Yoshiaki Niwa2Hideaki Kawakami3Kiyofumi Mochizuki4Kiyofumi Ohkusu5Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Ophthalmology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-8515, JapanDepartment of Ophthalmology, Gifu Prefectural General Medical Center, Gifu, JapanDepartment of Ophthalmology, Gifu Municipal Hospital, Gifu, JapanDepartment of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Microbiology, Tokyo Medical University Graduate School of Medicine, Tokyo, JapanPurpose. To determine the clinical features, microbial profiles, treatment outcomes, and prognostic factors for endogenous bacterial endophthalmitis (EBE). Methods. The medical records of 27 eyes of 21 patients diagnosed with EBE for 11 years were reviewed. Collected data included age, site of infection, visual acuities (VAs), microbial profiles, and treatment regimen. Results. The mean age was 68.5 years. Gram-positive organisms accounted for 76.2%, while gram-negative ones accounted for 19.0%. Staphylococcus aureus was the most common causative organism (52.3%) of which 72.7% was methicillin-resistant S. aureus. A final VA of ≥20/40 was achieved in 44% and 20/200 or better was in 64%. Eyes with initial VA of ≥20/200 (P = 0.003) and focal involvements (P = 0.011) had significantly better final VA. Initial VA (P = 0.001) and the interval between onset of ocular symptoms and intravitreal antibiotic injection (P = 0.097) were associated with final VA in eyes receiving intravitreal antibiotics. Conclusions. EBE is generally associated with poor visual outcome; however the prognosis may depend on initial VA, extent of ocular involvement, and an interval between onset of ocular symptoms and intravitreal antibiotic injection. Early diagnosis and early intravitreal injection supplement to systemic antibiotics might lead to a relatively good visual outcome.http://dx.doi.org/10.1155/2015/261310 |
| spellingShingle | Takashi Nishida Kyoko Ishida Yoshiaki Niwa Hideaki Kawakami Kiyofumi Mochizuki Kiyofumi Ohkusu An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis Journal of Ophthalmology |
| title | An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis |
| title_full | An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis |
| title_fullStr | An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis |
| title_full_unstemmed | An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis |
| title_short | An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis |
| title_sort | eleven year retrospective study of endogenous bacterial endophthalmitis |
| url | http://dx.doi.org/10.1155/2015/261310 |
| work_keys_str_mv | AT takashinishida anelevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT kyokoishida anelevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT yoshiakiniwa anelevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT hideakikawakami anelevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT kiyofumimochizuki anelevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT kiyofumiohkusu anelevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT takashinishida elevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT kyokoishida elevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT yoshiakiniwa elevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT hideakikawakami elevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT kiyofumimochizuki elevenyearretrospectivestudyofendogenousbacterialendophthalmitis AT kiyofumiohkusu elevenyearretrospectivestudyofendogenousbacterialendophthalmitis |