Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis
Gliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases. Understanding the molecular mechanisms underlying glioma pathogenesis is crucial for d...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523325001500 |
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| author | Wenjie Wu Youxi Xie Cheng Jiang Xiaobing Jiang |
| author_facet | Wenjie Wu Youxi Xie Cheng Jiang Xiaobing Jiang |
| author_sort | Wenjie Wu |
| collection | DOAJ |
| description | Gliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases. Understanding the molecular mechanisms underlying glioma pathogenesis is crucial for developing novel and effective treatment strategies. In recent years, increasing attention has been directed toward the tripartite motif (TRIM) family of proteins, a class of E3 ubiquitin ligases, due to their significant roles in glioma development and progression. This review comprehensively explores the diverse functions of TRIM proteins in gliomas, including their expression patterns, prognostic significance, and mechanisms of action that are both ubiquitination-dependent and -independent. By synthesizing current knowledge, we aim to elucidate the role of TRIM proteins in glioma pathogenesis and identify potential therapeutic targets within this protein family. |
| format | Article |
| id | doaj-art-3e208a2f29f24a5b8fb9cf90123818ae |
| institution | Kabale University |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-3e208a2f29f24a5b8fb9cf90123818ae2025-08-20T03:45:28ZengElsevierTranslational Oncology1936-52332025-08-015810241910.1016/j.tranon.2025.102419Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesisWenjie Wu0Youxi Xie1Cheng Jiang2Xiaobing Jiang3Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaCorresponding authors.; Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaCorresponding authors.; Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaGliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases. Understanding the molecular mechanisms underlying glioma pathogenesis is crucial for developing novel and effective treatment strategies. In recent years, increasing attention has been directed toward the tripartite motif (TRIM) family of proteins, a class of E3 ubiquitin ligases, due to their significant roles in glioma development and progression. This review comprehensively explores the diverse functions of TRIM proteins in gliomas, including their expression patterns, prognostic significance, and mechanisms of action that are both ubiquitination-dependent and -independent. By synthesizing current knowledge, we aim to elucidate the role of TRIM proteins in glioma pathogenesis and identify potential therapeutic targets within this protein family.http://www.sciencedirect.com/science/article/pii/S1936523325001500TRIM proteinsGliomaUbiquitinationPathogenesis |
| spellingShingle | Wenjie Wu Youxi Xie Cheng Jiang Xiaobing Jiang Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis Translational Oncology TRIM proteins Glioma Ubiquitination Pathogenesis |
| title | Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis |
| title_full | Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis |
| title_fullStr | Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis |
| title_full_unstemmed | Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis |
| title_short | Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis |
| title_sort | unveiling the multifaceted functions of trim proteins in glioma pathogenesis |
| topic | TRIM proteins Glioma Ubiquitination Pathogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S1936523325001500 |
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