Amino acid storage: lysosomal double role in health and disease
Cellular homeostasis depends on a multitude of cellular functions, which in turn depend on the clearance of damaged components for their maintenance. Lysosomes being one of the main sites of recycling, are at the frontline for cellular protein degradation, which leads to generation of protein buildi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Autophagy Reports |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/27694127.2025.2498324 |
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| author | Aiswarya Raj Samantha Shrihari Urmi Bandyopadhyay |
| author_facet | Aiswarya Raj Samantha Shrihari Urmi Bandyopadhyay |
| author_sort | Aiswarya Raj |
| collection | DOAJ |
| description | Cellular homeostasis depends on a multitude of cellular functions, which in turn depend on the clearance of damaged components for their maintenance. Lysosomes being one of the main sites of recycling, are at the frontline for cellular protein degradation, which leads to generation of protein building blocks, the amino acids (AAs), within the lysosomal lumen. However, the fate of these lysosomal pool of AAs are only partly known. Recently, studies from our and other groups have led to the finding that AA can be stored in lysosomes and revealed a homeostatic communication of these storages with the environment. Thus, lysosome appear to be a nutritional signaling hub that has a dual role. As a degradation-competent hydrolytic sack, lysosomes have a long-studied degradative function, additionally now they can either store or channel into utilization of the AAs generated through their proteolytic activity. Since the existence of a lysosomal AA storage pool has been determined by changing the levels of extracellular AAs, this indicates a multi-directional homeostatic communication between the lysosome and the extracellular environment. This Lysosomal homeostatic and adaptive response to the niche could be vital for life-threatening age-related degenerative disorders, where the lysosome-autophagy pathway and the microenvironmental cues play major roles in the disease progression, which will be discussed further in this piece. |
| format | Article |
| id | doaj-art-3e1e0ba3d7314166aa6ebe5baf57cc71 |
| institution | Kabale University |
| issn | 2769-4127 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj-art-3e1e0ba3d7314166aa6ebe5baf57cc712025-08-20T03:53:03ZengTaylor & Francis GroupAutophagy Reports2769-41272025-12-014110.1080/27694127.2025.2498324Amino acid storage: lysosomal double role in health and diseaseAiswarya Raj0Samantha Shrihari1Urmi Bandyopadhyay2Manipal Institute of Regenerative Medicine (MIRM), Bengaluru, IndiaManipal Institute of Regenerative Medicine (MIRM), Bengaluru, IndiaManipal Institute of Regenerative Medicine (MIRM), Bengaluru, IndiaCellular homeostasis depends on a multitude of cellular functions, which in turn depend on the clearance of damaged components for their maintenance. Lysosomes being one of the main sites of recycling, are at the frontline for cellular protein degradation, which leads to generation of protein building blocks, the amino acids (AAs), within the lysosomal lumen. However, the fate of these lysosomal pool of AAs are only partly known. Recently, studies from our and other groups have led to the finding that AA can be stored in lysosomes and revealed a homeostatic communication of these storages with the environment. Thus, lysosome appear to be a nutritional signaling hub that has a dual role. As a degradation-competent hydrolytic sack, lysosomes have a long-studied degradative function, additionally now they can either store or channel into utilization of the AAs generated through their proteolytic activity. Since the existence of a lysosomal AA storage pool has been determined by changing the levels of extracellular AAs, this indicates a multi-directional homeostatic communication between the lysosome and the extracellular environment. This Lysosomal homeostatic and adaptive response to the niche could be vital for life-threatening age-related degenerative disorders, where the lysosome-autophagy pathway and the microenvironmental cues play major roles in the disease progression, which will be discussed further in this piece.https://www.tandfonline.com/doi/10.1080/27694127.2025.2498324Lysosomenutrient storageleucineLAMTOR-RAG GTPase complexExtracellular Environment |
| spellingShingle | Aiswarya Raj Samantha Shrihari Urmi Bandyopadhyay Amino acid storage: lysosomal double role in health and disease Autophagy Reports Lysosome nutrient storage leucine LAMTOR-RAG GTPase complex Extracellular Environment |
| title | Amino acid storage: lysosomal double role in health and disease |
| title_full | Amino acid storage: lysosomal double role in health and disease |
| title_fullStr | Amino acid storage: lysosomal double role in health and disease |
| title_full_unstemmed | Amino acid storage: lysosomal double role in health and disease |
| title_short | Amino acid storage: lysosomal double role in health and disease |
| title_sort | amino acid storage lysosomal double role in health and disease |
| topic | Lysosome nutrient storage leucine LAMTOR-RAG GTPase complex Extracellular Environment |
| url | https://www.tandfonline.com/doi/10.1080/27694127.2025.2498324 |
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