Effects of a Multimodal Immersive Virtual Reality Intervention on Heart Rate Variability in Adults with Post-COVID-19 Syndrome

Background: Post-COVID-19 syndrome (PCC) is characterized by autonomic nervous system (ANS) dysregulation. Reduced heart rate variability (HRV) serves as a biomarker for ANS function. Few studies have assessed HRV modulations over treatment in PCC patients. This study evaluates the effects of a mult...

Full description

Saved in:
Bibliographic Details
Main Authors: Neus Cano, Oscar Casas, Mar Ariza, Olga Gelonch, Yemila Plana, Bruno Porras-Garcia, Maite Garolera
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Applied Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3417/15/8/4111
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850183790417149952
author Neus Cano
Oscar Casas
Mar Ariza
Olga Gelonch
Yemila Plana
Bruno Porras-Garcia
Maite Garolera
author_facet Neus Cano
Oscar Casas
Mar Ariza
Olga Gelonch
Yemila Plana
Bruno Porras-Garcia
Maite Garolera
author_sort Neus Cano
collection DOAJ
description Background: Post-COVID-19 syndrome (PCC) is characterized by autonomic nervous system (ANS) dysregulation. Reduced heart rate variability (HRV) serves as a biomarker for ANS function. Few studies have assessed HRV modulations over treatment in PCC patients. This study evaluates the effects of a multimodal immersive virtual reality intervention—integrating cognitive training, physical exercise, and mindfulness practices—on HRV parameters. Methods: Eighteen PCC adults were assigned to reduced (16 sessions) and extended (24 sessions) training. HRV was assessed using an electrocardiogram weight scale at baseline, in the mid-term, and at the end of the intervention. Time-domain and frequency-domain HRV measures were extracted. Results: No significant group-by-time interactions were found. However, certain time-domain HRV parameters showed significant changes over time. Unexpectedly, HRV decreased from baseline to mid-intervention in both groups, with recovery by the end of the intervention. No significant changes were observed in frequency-domain measures. Conclusions: The temporary reduction in HRV suggested that the initial cognitive and physical demands may have temporarily induced physiological stress. The subsequent restoration of HRV suggested adaptation and increased resilience. The absence of enhanced HRV with extended training suggests that session intensity may be more influential than the number of sessions in modulating HRV among PCC patients.
format Article
id doaj-art-3e172645b81f420f885fcb8a4809841d
institution OA Journals
issn 2076-3417
language English
publishDate 2025-04-01
publisher MDPI AG
record_format Article
series Applied Sciences
spelling doaj-art-3e172645b81f420f885fcb8a4809841d2025-08-20T02:17:14ZengMDPI AGApplied Sciences2076-34172025-04-01158411110.3390/app15084111Effects of a Multimodal Immersive Virtual Reality Intervention on Heart Rate Variability in Adults with Post-COVID-19 SyndromeNeus Cano0Oscar Casas1Mar Ariza2Olga Gelonch3Yemila Plana4Bruno Porras-Garcia5Maite Garolera6Brain, Cognition and Behavior Research Group, Consorci Sanitari de Terrassa (CST), 08227 Terrassa, SpainInstrumentation, Sensors and Interfaces Group, Department of Electronics, Universitat Politècnica de Catalunya, 08034 Barcelona, SpainBrain, Cognition and Behavior Research Group, Consorci Sanitari de Terrassa (CST), 08227 Terrassa, SpainBrain, Cognition and Behavior Research Group, Consorci Sanitari de Terrassa (CST), 08227 Terrassa, SpainBrain, Cognition and Behavior Research Group, Consorci Sanitari de Terrassa (CST), 08227 Terrassa, SpainBrain, Cognition and Behavior Research Group, Consorci Sanitari de Terrassa (CST), 08227 Terrassa, SpainBrain, Cognition and Behavior Research Group, Consorci Sanitari de Terrassa (CST), 08227 Terrassa, SpainBackground: Post-COVID-19 syndrome (PCC) is characterized by autonomic nervous system (ANS) dysregulation. Reduced heart rate variability (HRV) serves as a biomarker for ANS function. Few studies have assessed HRV modulations over treatment in PCC patients. This study evaluates the effects of a multimodal immersive virtual reality intervention—integrating cognitive training, physical exercise, and mindfulness practices—on HRV parameters. Methods: Eighteen PCC adults were assigned to reduced (16 sessions) and extended (24 sessions) training. HRV was assessed using an electrocardiogram weight scale at baseline, in the mid-term, and at the end of the intervention. Time-domain and frequency-domain HRV measures were extracted. Results: No significant group-by-time interactions were found. However, certain time-domain HRV parameters showed significant changes over time. Unexpectedly, HRV decreased from baseline to mid-intervention in both groups, with recovery by the end of the intervention. No significant changes were observed in frequency-domain measures. Conclusions: The temporary reduction in HRV suggested that the initial cognitive and physical demands may have temporarily induced physiological stress. The subsequent restoration of HRV suggested adaptation and increased resilience. The absence of enhanced HRV with extended training suggests that session intensity may be more influential than the number of sessions in modulating HRV among PCC patients.https://www.mdpi.com/2076-3417/15/8/4111heart rate variabilityimmersive virtual realitypost COVID conditionmultimodal training
spellingShingle Neus Cano
Oscar Casas
Mar Ariza
Olga Gelonch
Yemila Plana
Bruno Porras-Garcia
Maite Garolera
Effects of a Multimodal Immersive Virtual Reality Intervention on Heart Rate Variability in Adults with Post-COVID-19 Syndrome
Applied Sciences
heart rate variability
immersive virtual reality
post COVID condition
multimodal training
title Effects of a Multimodal Immersive Virtual Reality Intervention on Heart Rate Variability in Adults with Post-COVID-19 Syndrome
title_full Effects of a Multimodal Immersive Virtual Reality Intervention on Heart Rate Variability in Adults with Post-COVID-19 Syndrome
title_fullStr Effects of a Multimodal Immersive Virtual Reality Intervention on Heart Rate Variability in Adults with Post-COVID-19 Syndrome
title_full_unstemmed Effects of a Multimodal Immersive Virtual Reality Intervention on Heart Rate Variability in Adults with Post-COVID-19 Syndrome
title_short Effects of a Multimodal Immersive Virtual Reality Intervention on Heart Rate Variability in Adults with Post-COVID-19 Syndrome
title_sort effects of a multimodal immersive virtual reality intervention on heart rate variability in adults with post covid 19 syndrome
topic heart rate variability
immersive virtual reality
post COVID condition
multimodal training
url https://www.mdpi.com/2076-3417/15/8/4111
work_keys_str_mv AT neuscano effectsofamultimodalimmersivevirtualrealityinterventiononheartratevariabilityinadultswithpostcovid19syndrome
AT oscarcasas effectsofamultimodalimmersivevirtualrealityinterventiononheartratevariabilityinadultswithpostcovid19syndrome
AT marariza effectsofamultimodalimmersivevirtualrealityinterventiononheartratevariabilityinadultswithpostcovid19syndrome
AT olgagelonch effectsofamultimodalimmersivevirtualrealityinterventiononheartratevariabilityinadultswithpostcovid19syndrome
AT yemilaplana effectsofamultimodalimmersivevirtualrealityinterventiononheartratevariabilityinadultswithpostcovid19syndrome
AT brunoporrasgarcia effectsofamultimodalimmersivevirtualrealityinterventiononheartratevariabilityinadultswithpostcovid19syndrome
AT maitegarolera effectsofamultimodalimmersivevirtualrealityinterventiononheartratevariabilityinadultswithpostcovid19syndrome