Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability
Hydroxyapatite (HA) scaffolds produced by the accumulation of HA fibers were separately treated hydrothermally in three calcium phosphate solutions to form coatings of different micro/nano-structures. Different micro/nano-structure and morphologies have been regulated on the surface of treated HA s...
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middle technical university
2024-06-01
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| Series: | Journal of Techniques |
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| Online Access: | https://journal.mtu.edu.iq/index.php/MTU/article/view/2545 |
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| author | Adil Elrayah Ke Duan Xiong Lu Xiaob Lu Jie Weng |
| author_facet | Adil Elrayah Ke Duan Xiong Lu Xiaob Lu Jie Weng |
| author_sort | Adil Elrayah |
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Hydroxyapatite (HA) scaffolds produced by the accumulation of HA fibers were separately treated hydrothermally in three calcium phosphate solutions to form coatings of different micro/nano-structures. Different micro/nano-structure and morphologies have been regulated on the surface of treated HA scaffolds. Plate-like compromise flower-like morphology was obtained with solution 1 (Ca-sufficient) i.e., ratio: Ca/Ca=1%; Ca/P=1.67. Full coatings (flower-like) morphology treated after Cu-doped coating solution 2 (Cu/(Cu+Ca) = 5%; ratio: (Cu+Ca)/P = 1.67). Furthermore, partial coatings (flower-like) morphology fabricated with solution 3 (Ca-deficient and Cu-replacement), i.e., ratio: Ca/Ca=0.95%; Ca/P=1.58. The results showed the effect of hydrothermal coatings on HA scaffolds. Cultured human endothelial cells spread and proliferated better on the treated HA scaffolds than on the uncoated scaffolds, suggesting a potential effect of calcium phosphate surface morphology on endothelial cell response. Thus, it can provide an appropriate micro/nano-structure approach supporting angiogenesis capacity, which is a necessity to accelerate the time of bone healing and regeneration.
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| format | Article |
| id | doaj-art-3e158df4b8ee48819bc90d2e3d0c0bca |
| institution | Kabale University |
| issn | 1818-653X 2708-8383 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | middle technical university |
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| series | Journal of Techniques |
| spelling | doaj-art-3e158df4b8ee48819bc90d2e3d0c0bca2025-01-19T10:56:31Zengmiddle technical universityJournal of Techniques1818-653X2708-83832024-06-016210.51173/jt.v6i2.2545Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells ViabilityAdil Elrayah0Ke Duan1Xiong Lu2Xiaob Lu3Jie Weng4Medicine Collage, Karary University, Omdurman 12304, SudanKey Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, ChinaDepartment of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaKey Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, China Hydroxyapatite (HA) scaffolds produced by the accumulation of HA fibers were separately treated hydrothermally in three calcium phosphate solutions to form coatings of different micro/nano-structures. Different micro/nano-structure and morphologies have been regulated on the surface of treated HA scaffolds. Plate-like compromise flower-like morphology was obtained with solution 1 (Ca-sufficient) i.e., ratio: Ca/Ca=1%; Ca/P=1.67. Full coatings (flower-like) morphology treated after Cu-doped coating solution 2 (Cu/(Cu+Ca) = 5%; ratio: (Cu+Ca)/P = 1.67). Furthermore, partial coatings (flower-like) morphology fabricated with solution 3 (Ca-deficient and Cu-replacement), i.e., ratio: Ca/Ca=0.95%; Ca/P=1.58. The results showed the effect of hydrothermal coatings on HA scaffolds. Cultured human endothelial cells spread and proliferated better on the treated HA scaffolds than on the uncoated scaffolds, suggesting a potential effect of calcium phosphate surface morphology on endothelial cell response. Thus, it can provide an appropriate micro/nano-structure approach supporting angiogenesis capacity, which is a necessity to accelerate the time of bone healing and regeneration. https://journal.mtu.edu.iq/index.php/MTU/article/view/2545HydroxyapatiteMicro/Nano-StructureScaffoldsCoatingEndothelial Cell |
| spellingShingle | Adil Elrayah Ke Duan Xiong Lu Xiaob Lu Jie Weng Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability Journal of Techniques Hydroxyapatite Micro/Nano-Structure Scaffolds Coating Endothelial Cell |
| title | Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability |
| title_full | Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability |
| title_fullStr | Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability |
| title_full_unstemmed | Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability |
| title_short | Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability |
| title_sort | calcium phosphate coatings with controlled micro nano structures for endothelial cells viability |
| topic | Hydroxyapatite Micro/Nano-Structure Scaffolds Coating Endothelial Cell |
| url | https://journal.mtu.edu.iq/index.php/MTU/article/view/2545 |
| work_keys_str_mv | AT adilelrayah calciumphosphatecoatingswithcontrolledmicronanostructuresforendothelialcellsviability AT keduan calciumphosphatecoatingswithcontrolledmicronanostructuresforendothelialcellsviability AT xionglu calciumphosphatecoatingswithcontrolledmicronanostructuresforendothelialcellsviability AT xiaoblu calciumphosphatecoatingswithcontrolledmicronanostructuresforendothelialcellsviability AT jieweng calciumphosphatecoatingswithcontrolledmicronanostructuresforendothelialcellsviability |