Biological aging mediates the association between volatile organic compounds and cardiovascular disease
Abstract Background Evidence for the relationship between individual and combined volatile organic compounds (VOCs) and cardiovascular disease (CVD) is limited. Besides, the mediating role of biological aging (BA) has not been studied. Therefore, this study aimed to examine the association between V...
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BMC
2024-10-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-20349-4 |
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| author | Qingqing Cao Yu Song Changsheng Huan Zexin Jia Qian Gao Xiaoqing Ma Guihong Zhou Siyu Chen Jin Wei Yuchuan Wang Chongjian Wang Zhenxing Mao Jian Hou Wenqian Huo |
| author_facet | Qingqing Cao Yu Song Changsheng Huan Zexin Jia Qian Gao Xiaoqing Ma Guihong Zhou Siyu Chen Jin Wei Yuchuan Wang Chongjian Wang Zhenxing Mao Jian Hou Wenqian Huo |
| author_sort | Qingqing Cao |
| collection | DOAJ |
| description | Abstract Background Evidence for the relationship between individual and combined volatile organic compounds (VOCs) and cardiovascular disease (CVD) is limited. Besides, the mediating role of biological aging (BA) has not been studied. Therefore, this study aimed to examine the association between VOCs and CVD risk and to explore the mediating effects of BA. Methods Logistic regression models were used to investigate the relationships of metabolites of volatile organic compounds (mVOCs) and BA with CVD. In addition, weighted quantile sum (WQS) regression, adaptive elastic networks, and Environmental Risk Score (AENET-ERS) were utilized to assess overall associations of mixed VOCs co-exposure with CVD. Mediation analyses were used to identify potential mediating effects of BA. Results In the single-pollutant model, CYMA was shown to be associated with an increased risk of CVD. Additionally, we identified significantly positive associations between the WQS index and CVD (odds ratio (OR) = 1.292, 95% confidence interval (CI): 1.006, 1.660), and DHBMA had the greatest contribution for CVD (0.246). Furthermore, the AENET-ERS results showed that 8 mVOCs were significantly associated with CVD, and ERS was related to an elevated risk of CVD (OR = 1.538, 95%CI: 1.255, 1.884). Three BA indicators mediated the association of the mVOCs mixture with CVD, with mediating effect proportions of 11.32%, 34.34%, and 7.92%, respectively. Conclusion The risk of CVD was found to increase with both individual and combined exposure to VOCs. BA mediates the positive effects of VOCs on CVD, suggesting that this pathway may be one of the mechanisms of CVD. |
| format | Article |
| id | doaj-art-3e0eb58cd4424b92abfb678d855db3b7 |
| institution | OA Journals |
| issn | 1471-2458 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-3e0eb58cd4424b92abfb678d855db3b72025-08-20T02:11:49ZengBMCBMC Public Health1471-24582024-10-0124111010.1186/s12889-024-20349-4Biological aging mediates the association between volatile organic compounds and cardiovascular diseaseQingqing Cao0Yu Song1Changsheng Huan2Zexin Jia3Qian Gao4Xiaoqing Ma5Guihong Zhou6Siyu Chen7Jin Wei8Yuchuan Wang9Chongjian Wang10Zhenxing Mao11Jian Hou12Wenqian Huo13Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou UniversityDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou UniversityDepartment of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou UniversityAbstract Background Evidence for the relationship between individual and combined volatile organic compounds (VOCs) and cardiovascular disease (CVD) is limited. Besides, the mediating role of biological aging (BA) has not been studied. Therefore, this study aimed to examine the association between VOCs and CVD risk and to explore the mediating effects of BA. Methods Logistic regression models were used to investigate the relationships of metabolites of volatile organic compounds (mVOCs) and BA with CVD. In addition, weighted quantile sum (WQS) regression, adaptive elastic networks, and Environmental Risk Score (AENET-ERS) were utilized to assess overall associations of mixed VOCs co-exposure with CVD. Mediation analyses were used to identify potential mediating effects of BA. Results In the single-pollutant model, CYMA was shown to be associated with an increased risk of CVD. Additionally, we identified significantly positive associations between the WQS index and CVD (odds ratio (OR) = 1.292, 95% confidence interval (CI): 1.006, 1.660), and DHBMA had the greatest contribution for CVD (0.246). Furthermore, the AENET-ERS results showed that 8 mVOCs were significantly associated with CVD, and ERS was related to an elevated risk of CVD (OR = 1.538, 95%CI: 1.255, 1.884). Three BA indicators mediated the association of the mVOCs mixture with CVD, with mediating effect proportions of 11.32%, 34.34%, and 7.92%, respectively. Conclusion The risk of CVD was found to increase with both individual and combined exposure to VOCs. BA mediates the positive effects of VOCs on CVD, suggesting that this pathway may be one of the mechanisms of CVD.https://doi.org/10.1186/s12889-024-20349-4Volatile organic compoundsMixed exposureCardiovascular diseaseEnvironmental risk scoreBiological aging |
| spellingShingle | Qingqing Cao Yu Song Changsheng Huan Zexin Jia Qian Gao Xiaoqing Ma Guihong Zhou Siyu Chen Jin Wei Yuchuan Wang Chongjian Wang Zhenxing Mao Jian Hou Wenqian Huo Biological aging mediates the association between volatile organic compounds and cardiovascular disease BMC Public Health Volatile organic compounds Mixed exposure Cardiovascular disease Environmental risk score Biological aging |
| title | Biological aging mediates the association between volatile organic compounds and cardiovascular disease |
| title_full | Biological aging mediates the association between volatile organic compounds and cardiovascular disease |
| title_fullStr | Biological aging mediates the association between volatile organic compounds and cardiovascular disease |
| title_full_unstemmed | Biological aging mediates the association between volatile organic compounds and cardiovascular disease |
| title_short | Biological aging mediates the association between volatile organic compounds and cardiovascular disease |
| title_sort | biological aging mediates the association between volatile organic compounds and cardiovascular disease |
| topic | Volatile organic compounds Mixed exposure Cardiovascular disease Environmental risk score Biological aging |
| url | https://doi.org/10.1186/s12889-024-20349-4 |
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