Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity

Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity

Abstract Diminished signaling via insulin/insulin-like growth factor-1 (IGF-1) axis is associated with longevity in different model organisms. IGF-1 gene is highly conserved across species, with only few evolutionary changes identified in it. Despite its potential role in regulating lifespan, no cod...

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Bibliographic Details
Main Authors: Amanat Ali, Zhengdong D. Zhang, Tina Gao, Sandra Aleksic, Evripidis Gavathiotis, Nir Barzilai, Sofiya Milman
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
IGF-1
IGF-1R
Genetic variants
Aging
Molecular dynamics
Online Access:https://doi.org/10.1038/s41598-025-94094-y
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