The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease
Background. The purpose of this retrospective study was to clarify whether the presence of honeycombing on computed tomography (CT) can affect the prognosis of patients with acute exacerbations (AEs) of interstitial lung diseases (ILDs). Methods. Clinical parameters including age, sex, Charlson Como...
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| Format: | Article |
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Wiley
2021-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/7456315 |
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| author | Yurika Nishikawa Yu Hara Yoichi Tagami Ryo Nagasawa Kota Murohashi Ayako Aoki Katsushi Tanaka Keisuke Watanabe Nobuyuki Horita Nobuaki Kobayashi Masaki Yamamoto Makoto Kudo Takeshi Kaneko |
| author_facet | Yurika Nishikawa Yu Hara Yoichi Tagami Ryo Nagasawa Kota Murohashi Ayako Aoki Katsushi Tanaka Keisuke Watanabe Nobuyuki Horita Nobuaki Kobayashi Masaki Yamamoto Makoto Kudo Takeshi Kaneko |
| author_sort | Yurika Nishikawa |
| collection | DOAJ |
| description | Background. The purpose of this retrospective study was to clarify whether the presence of honeycombing on computed tomography (CT) can affect the prognosis of patients with acute exacerbations (AEs) of interstitial lung diseases (ILDs). Methods. Clinical parameters including age, sex, Charlson Comorbidity Index Score (CCIS), blood biomarkers, and 3-month mortality were retrospectively compared between the CT honeycombing present and absent groups at the diagnosis of AEs of ILDs. Results. Ninety-five patients who were on corticosteroid pulse therapy were assessed. Though log-rank tests showed that Kaplan–Meier survival curves of the high and low ground-glass opacity (GGO) score groups differed significantly in 3-month mortality in patients with AEs of idiopathic ILDs (P = 0.007) and overall patients (P = 0.045), there was no significant difference between the CT honeycombing present and absent groups in patients with AEs of idiopathic ILDs (P = 0.472) and AEs of secondary ILDs (P = 0.905), as well as of overall patients (P = 0.600). In addition, whereas CCIS (OR, 1.436; 95% CI, 1.156–1.842; P < 0.001) was a significant predictor of 3-month mortality in the CT honeycombing absent group, serum LDH (OR, 1.005; 95% CI, 1.002–1.007; P = 0.001) was a significant predictor in the CT honeycombing present group. Conclusions. The clinical features of patients with or without honeycombing may differ due to the difference in prognostic factors, but these groups were found to have similar prognoses 3 months after AE onset, and clinicopathological examinations according to these groups are essential. |
| format | Article |
| id | doaj-art-3e0e24e1ee264e7f8355a849fba94a21 |
| institution | OA Journals |
| issn | 1916-7245 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-3e0e24e1ee264e7f8355a849fba94a212025-08-20T02:07:49ZengWileyCanadian Respiratory Journal1916-72452021-01-01202110.1155/2021/7456315The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung DiseaseYurika Nishikawa0Yu Hara1Yoichi Tagami2Ryo Nagasawa3Kota Murohashi4Ayako Aoki5Katsushi Tanaka6Keisuke Watanabe7Nobuyuki Horita8Nobuaki Kobayashi9Masaki Yamamoto10Makoto Kudo11Takeshi Kaneko12Department of PulmonologyDepartment of PulmonologyDepartment of PulmonologyDepartment of PulmonologyDepartment of PulmonologyDepartment of PulmonologyDepartment of PulmonologyDepartment of PulmonologyDepartment of PulmonologyDepartment of PulmonologyRespiratory Disease CenterRespiratory Disease CenterDepartment of PulmonologyBackground. The purpose of this retrospective study was to clarify whether the presence of honeycombing on computed tomography (CT) can affect the prognosis of patients with acute exacerbations (AEs) of interstitial lung diseases (ILDs). Methods. Clinical parameters including age, sex, Charlson Comorbidity Index Score (CCIS), blood biomarkers, and 3-month mortality were retrospectively compared between the CT honeycombing present and absent groups at the diagnosis of AEs of ILDs. Results. Ninety-five patients who were on corticosteroid pulse therapy were assessed. Though log-rank tests showed that Kaplan–Meier survival curves of the high and low ground-glass opacity (GGO) score groups differed significantly in 3-month mortality in patients with AEs of idiopathic ILDs (P = 0.007) and overall patients (P = 0.045), there was no significant difference between the CT honeycombing present and absent groups in patients with AEs of idiopathic ILDs (P = 0.472) and AEs of secondary ILDs (P = 0.905), as well as of overall patients (P = 0.600). In addition, whereas CCIS (OR, 1.436; 95% CI, 1.156–1.842; P < 0.001) was a significant predictor of 3-month mortality in the CT honeycombing absent group, serum LDH (OR, 1.005; 95% CI, 1.002–1.007; P = 0.001) was a significant predictor in the CT honeycombing present group. Conclusions. The clinical features of patients with or without honeycombing may differ due to the difference in prognostic factors, but these groups were found to have similar prognoses 3 months after AE onset, and clinicopathological examinations according to these groups are essential.http://dx.doi.org/10.1155/2021/7456315 |
| spellingShingle | Yurika Nishikawa Yu Hara Yoichi Tagami Ryo Nagasawa Kota Murohashi Ayako Aoki Katsushi Tanaka Keisuke Watanabe Nobuyuki Horita Nobuaki Kobayashi Masaki Yamamoto Makoto Kudo Takeshi Kaneko The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease Canadian Respiratory Journal |
| title | The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease |
| title_full | The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease |
| title_fullStr | The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease |
| title_full_unstemmed | The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease |
| title_short | The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease |
| title_sort | extent of honeycombing on computed tomography cannot predict the treatment outcome of patients with acute exacerbations of interstitial lung disease |
| url | http://dx.doi.org/10.1155/2021/7456315 |
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