Genome‐wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

Genome‐wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

Abstract Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating therapy resistance. Many of these events involve synthetic rescue (SR) interactions, where the reduction in cancer cell viability caused...

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Main Authors: Avinash Das Sahu, Joo S Lee, Zhiyong Wang, Gao Zhang, Ramiro Iglesias‐Bartolome, Tian Tian, Zhi Wei, Benchun Miao, Nishanth Ulhas Nair, Olga Ponomarova, Adam A Friedman, Arnaud Amzallag, Tabea Moll, Gyulnara Kasumova, Patricia Greninger, Regina K Egan, Leah J Damon, Dennie T Frederick, Livnat Jerby‐Arnon, Allon Wagner, Kuoyuan Cheng, Seung Gu Park, Welles Robinson, Kevin Gardner, Genevieve Boland, Sridhar Hannenhalli, Meenhard Herlyn, Cyril Benes, Keith Flaherty, Ji Luo, J Silvio Gutkind, Eytan Ruppin
Format: Article
Language:English
Published: Springer Nature 2019-03-01
Series:Molecular Systems Biology
Subjects:
drug combination
drug resistance
immunotherapy
synergy
Online Access:https://doi.org/10.15252/msb.20188323
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