Computational Insights into the Polypharmacological Landscape of BCR-ABL Inhibitors: Emphasis on Imatinib and Nilotinib

Computational Insights into the Polypharmacological Landscape of BCR-ABL Inhibitors: Emphasis on Imatinib and Nilotinib

<b>Background:</b> BCR-ABL inhibitors such as imatinib and nilotinib exhibit multi-kinase activity that extends beyond oncology, offering significant potential for drug repurposing. <b>Objectives:</b> This study aims to systematically evaluate and prioritize the repurposing p...

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Bibliographic Details
Main Authors: Rima Hajjo, Dima A. Sabbah, Raghad Alhaded, Aye Alquabe’h, Sanaa K. Bardaweel
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
BCR-ABL inhibitors
drug repurposing
imatinib
kinase inhibitors
nilotinib
pharmacoinformatics
Online Access:https://www.mdpi.com/1424-8247/18/7/936
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