Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colon.

Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colon.

Oxaliplatin is a platinum-based chemotherapeutic used for cancer treatment. Its use associates with peripheral neuropathies and chronic gastrointestinal side-effects. Oxaliplatin induces immunogenic cell death by provoking the presentation of damage associated molecular patterns. The damage associat...

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Bibliographic Details
Main Authors: Vanesa Stojanovska, Rachel M McQuade, Sarah Fraser, Monica Prakash, Shakuntla Gondalia, Rhian Stavely, Enzo Palombo, Vasso Apostolopoulos, Samy Sakkal, Kulmira Nurgali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198359/1/pone.0198359.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134720Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=4d1c8958384ce86abb2b653c9bf309b8ae98ba0781c832be548edf384d1704334e5569e6960d9ab961601def0d8468a40b8cbabecfc856f63282c8192677ec6f30dc14073cd5cd44d12f3bae08e5c69590e9df94177b3feb3c86dd0252df9380f83e33e7b3370136658f8ff6f66ed966b07d71ebb3be7ceda5b800f7f5e4fcbb79ffbe04c351c5e61346ac1d7efe61b0ee48be5b772c21421ef7f7a01686d887c9795643ca852c18947856c33d125b5d8b06fe28189b919e2c314596204a1f148a95d5de63b8454e739fbbe5ae0ce64a265b0ec406fb02d7e2a269600fcb963626bda5c348bf96ad4972fb8fb7cfe7a5cbaa5b11f621d95ac38c52b27632f980
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