Targeting mitochondria in bone and cartilage diseases: A narrative review

Targeting mitochondria in bone and cartilage diseases: A narrative review

Mitochondria are essential regulators of bone health, controlling cell differentiation, cellular energy production, immune function, osteogenesis, and osteoclast activity. Their dysfunction is linked to orthopedic disorders such as osteoporosis, osteoarthritis, and osteomyelitis, contributing to imp...

Full description

Saved in:

Bibliographic Details
Main Authors:	Daniel H. Mendelsohn, Nike Walter, Wing-Hoi Cheung, Ronald Man Yeung Wong, Rebecca Schönmehl, Lina Winter, Thaqif El Khassawna, Christian Heiss, Christoph Brochhausen, Markus Rupp
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Series:	Redox Biology
Subjects:	Mitochondria Bone Cartilage Mitochondrial dynamics Osteoarthritis Osteoporosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725001806
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Carbon Monoxide Stimulates Chondrocyte Mitochondria and Protects Mitochondria During Cartilage Injury
by: Suryamin Liman, et al.
Published: (2025-04-01)

Extracellular mitochondria as promising diagnostic agents
by: О. I. Kit, et al.
Published: (2024-03-01)

In Vivo and In Vitro Evaluation of the Feasibility and Safety Profiles of Intraarticular Transplantation of Mitochondria for Future Use as a Therapy for Osteoarthritis
by: Carlos Vaamonde-Garcia, et al.
Published: (2025-01-01)

Role of mitochondria in physiological activities, diseases, and therapy
by: Lilin Wang, et al.
Published: (2025-06-01)

The Roles of Mitochondria in Human Being’s Life and Aging
by: Hiroko P. Indo, et al.
Published: (2024-10-01)

Mitochondria of transformed cell as a target of antitumor influence
by: E. M. Frantsiyants, et al.
Published: (2020-06-01)

Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis
by: Likai Yu, et al.
Published: (2025-08-01)

Mitochondria-based medicine
by: Salvador Vázquez-Vega, et al.
Published: (2025-01-01)

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
by: Qi Liu, et al.
Published: (2025-07-01)

Effect of atmospheric particulate matter on the functional state of mitochondria
by: Elena V. Kondratyeva, et al.
Published: (2023-03-01)

Advances in research on the relationship between mitochondrial dysfunction and osteoporosis: a bibliometric study from 2014 to 2024
by: Yun-song Zhang, et al.
Published: (2025-07-01)

Targeting mitochondria: a novel approach for treating platinum-resistant ovarian cancer
by: Xin Cui, et al.
Published: (2024-10-01)

Nanoengineered mitochondria enable ocular mitochondrial disease therapy via the replacement of dysfunctional mitochondria
by: Yi Wang, et al.
Published: (2024-12-01)

Vimentin Intermediate Filaments Maintain Membrane Potential of Mitochondria in Growing Neurites
by: Alexander A. Dayal, et al.
Published: (2024-11-01)

Mitochondria: a key regulator of programmed cell death in OP
by: Kexin Wang, et al.
Published: (2025-07-01)

Realization of malignant potential of human glioblastoma mitochondria in immunodeficient animals
by: O. I. Kit, et al.
Published: (2023-09-01)

Correlation of Femoral Cartilage Thickness and Osteoporosis in Female Patients with Knee Osteoarthritis
by: Gamze Altuğ Özövez, et al.
Published: (2021-08-01)

Exosomes in cartilage microenvironment regulation and cartilage repair
by: Han Longfei, et al.
Published: (2025-03-01)

Isolation and Characterization of Articular Cartilage-Derived Cells Obtained by Arthroscopic Cartilage Biopsy from Non-Osteoarthritic Patients
by: Pedro Nogueira Giglio, et al.
Published: (2025-06-01)

Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons
by: Beatrice Masante, et al.
Published: (2025-07-01)

The Role of Mitochondrial Permeability Transition in Bone Metabolism, Bone Healing, and Bone Diseases
by: Xiting Zhu, et al.
Published: (2024-10-01)

Mitochondria targeted nanoparticles for the treatment of mitochondrial dysfunction-associated brain disorders
by: Amy Claire Buck, et al.
Published: (2025-03-01)

Osteoblast‐Derived Mitochondria Formulated with Cationic Liposome Guide Mesenchymal Stem Cells into Osteogenic Differentiation
by: Hye‐Ryoung Kim, et al.
Published: (2025-03-01)

Potential strategies for effective utilization of costal cartilage in articular cartilage injury repair
by: SA Sheleg, et al.
Published: (2025-06-01)

Endoplasmic reticulum-mitochondria crosstalk: new mechanisms in the development of atherosclerosis
by: Mingxiao Li, et al.
Published: (2025-06-01)

Midterm Outcomes and Surgical Approaches for Osteochondral Lesions of the Talus
by: Christoph Biehl PD, et al.
Published: (2025-04-01)

Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions
by: Tammy B. Pham, et al.
Published: (2024-11-01)

Comprehensive bioinformatics analysis reveals novel potential biomarkers associated with aging and mitochondria in osteoporosis
by: Ke Bi, et al.
Published: (2025-01-01)

Research Progress on Regulation of Tumor Immune Microenvironment via Reactivation of Unbalanced Mitochondria in Traditional Chinese Medicine
by: Mengying PENG, et al.
Published: (2025-06-01)

Articular cartilage debridement results in short-term significant improvements in patient-reported outcomes for large areas of cartilage loss of the femur in the setting of mild to moderate knee osteoarthritis
by: Yusuf Mufti, et al.
Published: (2024-12-01)

ATP Synthase Abundance in Neuronal Extracellular Vesicles Reflects Changes in the Mitochondria of Parent Neurons
by: Pamela J. Yao, et al.
Published: (2025-08-01)

Modulation of the gut-bone axis: Lacticaseibacillus paracasei LC86 improves bone health via anti-inflammatory metabolic pathways in zebrafish models of osteoporosis and cartilage damage
by: Yao Dong, et al.
Published: (2025-04-01)

Advances in immune mechanisms and developing immune-targeted therapies for osteoporosis: A systematic review
by: Ranyang Tao, et al.
Published: (2025-08-01)

Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation
by: Pasquale Picone, et al.
Published: (2024-12-01)

THE EFFECT OF DECELLULARIZATION TECHNIQUE ON COLLAGEN TYPE II AND MATRICES POROSITY OF CARTILAGE BOVINE SCAFFOLD
by: Dwikora Novembri Utomo, et al.
Published: (2019-12-01)

One‐stage minced cartilage autograft with platelet‐rich plasma improves early clinical outcomes: A multicentric retrospective study
by: Arthur Barbaret, et al.
Published: (2025-01-01)

Mechanisms and therapeutic targets of mitochondria in the progression of metabolic dysfunction-associated steatotic liver disease
by: Chenyang Mu, et al.
Published: (2025-01-01)

Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation
by: Hongyu Jiang, et al.
Published: (2025-07-01)

Small spheroids for head and neck cartilage tissue engineering
by: Sven Reutter, et al.
Published: (2024-12-01)

Namaste (counterbalancing) technique: Overcoming warping in costal cartilage
by: Kapil S. Agrawal, et al.
Published: (2015-05-01)