Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study
Introduction Prognosis of patients with COVID-19 depends on the severity of the pulmonary affection. The most severe cases may progress to acute respiratory distress syndrome (ARDS), which is associated with a risk of long-term repercussions on respiratory function and neuromuscular outcomes. The fu...
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2022-04-01
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| author | Pierre-louis Declercq Vanessa Bironneau Jean Dellamonica Christine Binquet Laura Federici Gaetan Beduneau Nicolas Meunier-Beillard Thierry Vanderlinden Marjolaine Georges Paul Abraham Bertrand Sauneuf Matthieu Demeyere Antoine Rivière Caroline Clarot Alexandre Ampere Pierre Kalfon Élise Redureau Mehdi Bousta Laurie Lagache Béatrice La Combe Martine Nyunga Michel Ramakers Walid Oulehri Hugues Georges Nicolas Delberghe Gurvan Le Bouar Arnaud-Felix Miailhe Sami Hraiech Marie-Anne Hoppe George-Daniel Calcaianu Stéphanie Gélinotte Marie Labruyère |
| author_facet | Pierre-louis Declercq Vanessa Bironneau Jean Dellamonica Christine Binquet Laura Federici Gaetan Beduneau Nicolas Meunier-Beillard Thierry Vanderlinden Marjolaine Georges Paul Abraham Bertrand Sauneuf Matthieu Demeyere Antoine Rivière Caroline Clarot Alexandre Ampere Pierre Kalfon Élise Redureau Mehdi Bousta Laurie Lagache Béatrice La Combe Martine Nyunga Michel Ramakers Walid Oulehri Hugues Georges Nicolas Delberghe Gurvan Le Bouar Arnaud-Felix Miailhe Sami Hraiech Marie-Anne Hoppe George-Daniel Calcaianu Stéphanie Gélinotte Marie Labruyère |
| author_sort | Pierre-louis Declercq |
| collection | DOAJ |
| description | Introduction Prognosis of patients with COVID-19 depends on the severity of the pulmonary affection. The most severe cases may progress to acute respiratory distress syndrome (ARDS), which is associated with a risk of long-term repercussions on respiratory function and neuromuscular outcomes. The functional repercussions of severe forms of COVID-19 may have a major impact on quality of life, and impair the ability to return to work or exercise. Social inequalities in healthcare may influence prognosis, with socially vulnerable individuals more likely to develop severe forms of disease. We describe here the protocol for a prospective, multicentre study that aims to investigate the influence of social vulnerability on functional recovery in patients who were hospitalised in intensive care for ARDS caused by COVID-19. This study will also include an embedded qualitative study that aims to describe facilitators and barriers to compliance with rehabilitation, describe patients’ health practices and identify social representations of health, disease and care.Methods and analysis The 'Functional Recovery From Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19: Influence of Socio-Economic Status' (RECOVIDS) study is a mixed-methods, observational, multicentre cohort study performed during the routine follow-up of post-intensive care unit (ICU) functional recovery after ARDS. All patients admitted to a participating ICU for PCR-proven SARS-CoV-2 infection and who underwent chest CT scan at the initial phase AND who received respiratory support (mechanical or not) or high-flow nasal oxygen, AND had ARDS diagnosed by the Berlin criteria will be eligible. The primary outcome is the presence of lung sequelae at 6 months after ICU discharge, defined either by alterations on pulmonary function tests, oxygen desaturation during a standardised 6 min walk test or fibrosis-like pulmonary findings on chest CT. Patients will be considered to be socially disadvantaged if they have an 'Evaluation de la Précarité et des Inégalités de santé dans les Centres d’Examen de Santé' (EPICES) score ≥30.17 at inclusion.Ethics and dissemination The study protocol and the informed consent form were approved by an independent ethics committee (Comité de Protection des Personnes Sud Méditerranée II) on 10 July 2020 (2020-A02014-35). All patients will provide informed consent before participation. Findings will be published in peer-reviewed journals and presented at national and international congresses.Trial registration number NCT04556513 |
| format | Article |
| id | doaj-art-3dfecd087ba341d6be10ad7302c75da5 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-3dfecd087ba341d6be10ad7302c75da52025-08-20T02:25:47ZengBMJ Publishing GroupBMJ Open2044-60552022-04-0112410.1136/bmjopen-2021-057368Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational studyPierre-louis Declercq0Vanessa Bironneau1Jean Dellamonica2Christine Binquet3Laura Federici4Gaetan Beduneau5Nicolas Meunier-Beillard6Thierry Vanderlinden7Marjolaine Georges8Paul Abraham9Bertrand Sauneuf10Matthieu Demeyere11Antoine Rivière12Caroline Clarot13Alexandre Ampere14Pierre Kalfon15Élise Redureau16Mehdi Bousta17Laurie Lagache18Béatrice La Combe19Martine Nyunga20Michel Ramakers21Walid Oulehri22Hugues Georges23Nicolas Delberghe24Gurvan Le Bouar25Arnaud-Felix Miailhe26Sami Hraiech27Marie-Anne Hoppe28George-Daniel Calcaianu29Stéphanie Gélinotte30Marie Labruyère311 EA3830-GRHV, Institute for Research and Innovation in Biomedicine (IRIB) and Rouen University Hospital, Service de Pneumologie, Oncologie thoracique et Soins Intensifs Respiratoires, F 76000, Normandie Univ, UNIRouen, Rouen, France5 Service de Pneumologie, Université de Poitiers, CHU, Poitiers, FranceMedical ICU, University Hospital Centre Nice, Nice, FranceINSERM, CIC 1432, Module Epidémiologie Clinique, Dijon, FranceService de médecine intensive reanimation, Hôpital Louis-Mourier, Colombes, FranceDépartement de Réanimation Médicale, Centre Hospitalier Universitaire de Rouen, Rouen, FranceCIC, Centre Hospitalier Universitaire de Dijon, Dijon, FranceService de Médecine Intensive-Réanimation, Hospital Group of Lille Catholic University, Lille, FranceDepartment of Pulmonary Medicine, University Hospital, Seattle, Washington, USADépartement danesthésie-réanimation, Hôpital Edouard-Herriot, Hospices Civils de Lyon, Lyon, FranceService de Médecine Intensive-Réanimation, Cotentin Public Hospital Centre, Cherbourg-Octeville, FranceDepartment of Radiology, University Hospital Centre Rouen, Rouen, FranceService de Médecine Intensive-Réanimation, Abbeville Hospital Centre, Abbeville, FranceService de Pneumologie, Abbeville Hospital Centre, Abbeville, FranceService de Pneumologie, Hospital Centre Bethune, Bethune, FranceService de Médecine Intensive-Réanimation, Hospital Centre Chartres, Chartres, FranceService de Médecine Intensive-Réanimation, Departmental Hospital Centre La Roche-sur-Yon, La Roche-sur-Yon, FranceService de Réanimation Médico-Chirurgicale, Hospital Group Le Havre, Le Havre, FranceService de Réanimation Médico-Chirurgicale, Hospital Group Le Havre, Le Havre, FranceService de Réanimation Polyvalente, Groupe Hospitalier Bretagne Sud, Lorient, FranceService de Médecine Intensive-Réanimation, Roubaix Hospital Center, Roubaix, FranceService de Médecine Intensive-Réanimation, Centre Hospitalier Mémorial de Saint-Lô, Saint-Lo, FranceService de Réanimation Chirurgicale, University Hospitals Strasbourg, Strasbourg, FranceService de Médecine Intensive-Réanimation, Hospital Centre Gustave Dron de Tourcoing, Tourcoing, FranceService de Pneumologie, Hospital Centre Eure-Seine, Evreux, FranceService de Médecine Intensive-Réanimation, University Hospital Centre Rouen, Rouen, FranceService de Médecine Intensive-Réanimation, University Hospital Centre Nantes, Nantes, FranceService de Médecine Intensive-Réanimation, Hôpital Nord, Marseille, FranceService de Médecine Intensive-Réanimation, Hospital Centre La Rochelle, La Rochelle, FranceService de Pneumologie, Mulhouse and South Alsace Region Hospital Group, Mulhouse, FranceService de Médecine Intensive-Réanimation, Hospital Centre Dieppe, Dieppe, FranceService de Médecine Intensive-Réanimation, University Hospital Centre Dijon, Dijon, FranceIntroduction Prognosis of patients with COVID-19 depends on the severity of the pulmonary affection. The most severe cases may progress to acute respiratory distress syndrome (ARDS), which is associated with a risk of long-term repercussions on respiratory function and neuromuscular outcomes. The functional repercussions of severe forms of COVID-19 may have a major impact on quality of life, and impair the ability to return to work or exercise. Social inequalities in healthcare may influence prognosis, with socially vulnerable individuals more likely to develop severe forms of disease. We describe here the protocol for a prospective, multicentre study that aims to investigate the influence of social vulnerability on functional recovery in patients who were hospitalised in intensive care for ARDS caused by COVID-19. This study will also include an embedded qualitative study that aims to describe facilitators and barriers to compliance with rehabilitation, describe patients’ health practices and identify social representations of health, disease and care.Methods and analysis The 'Functional Recovery From Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19: Influence of Socio-Economic Status' (RECOVIDS) study is a mixed-methods, observational, multicentre cohort study performed during the routine follow-up of post-intensive care unit (ICU) functional recovery after ARDS. All patients admitted to a participating ICU for PCR-proven SARS-CoV-2 infection and who underwent chest CT scan at the initial phase AND who received respiratory support (mechanical or not) or high-flow nasal oxygen, AND had ARDS diagnosed by the Berlin criteria will be eligible. The primary outcome is the presence of lung sequelae at 6 months after ICU discharge, defined either by alterations on pulmonary function tests, oxygen desaturation during a standardised 6 min walk test or fibrosis-like pulmonary findings on chest CT. Patients will be considered to be socially disadvantaged if they have an 'Evaluation de la Précarité et des Inégalités de santé dans les Centres d’Examen de Santé' (EPICES) score ≥30.17 at inclusion.Ethics and dissemination The study protocol and the informed consent form were approved by an independent ethics committee (Comité de Protection des Personnes Sud Méditerranée II) on 10 July 2020 (2020-A02014-35). All patients will provide informed consent before participation. Findings will be published in peer-reviewed journals and presented at national and international congresses.Trial registration number NCT04556513https://bmjopen.bmj.com/content/12/4/e057368.full |
| spellingShingle | Pierre-louis Declercq Vanessa Bironneau Jean Dellamonica Christine Binquet Laura Federici Gaetan Beduneau Nicolas Meunier-Beillard Thierry Vanderlinden Marjolaine Georges Paul Abraham Bertrand Sauneuf Matthieu Demeyere Antoine Rivière Caroline Clarot Alexandre Ampere Pierre Kalfon Élise Redureau Mehdi Bousta Laurie Lagache Béatrice La Combe Martine Nyunga Michel Ramakers Walid Oulehri Hugues Georges Nicolas Delberghe Gurvan Le Bouar Arnaud-Felix Miailhe Sami Hraiech Marie-Anne Hoppe George-Daniel Calcaianu Stéphanie Gélinotte Marie Labruyère Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study BMJ Open |
| title | Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study |
| title_full | Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study |
| title_fullStr | Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study |
| title_full_unstemmed | Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study |
| title_short | Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study |
| title_sort | influence of socioeconomic status on functional recovery after ards caused by sars cov 2 a multicentre observational study |
| url | https://bmjopen.bmj.com/content/12/4/e057368.full |
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