Acute myocardial ischemia: changes of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery
The aim of the present study is to analyze the dynamics of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery. We showed that the concentration of free circulating mtDNA of blood tends to decrease 24 hours after ligation; it inc...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2013-09-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/1662 |
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| author | N. P. Sudakov T. P. Popkova A. I. Katyshev O. A. Goldberg M. A. Novikova S. B. Nikiforov B. G. Pushkarev I. V. Klimenkov S. A. Lepekhova K. A. Apartsin S. D. Ezhikeeva M. N. Ten Yu. M. Konstantinov |
| author_facet | N. P. Sudakov T. P. Popkova A. I. Katyshev O. A. Goldberg M. A. Novikova S. B. Nikiforov B. G. Pushkarev I. V. Klimenkov S. A. Lepekhova K. A. Apartsin S. D. Ezhikeeva M. N. Ten Yu. M. Konstantinov |
| author_sort | N. P. Sudakov |
| collection | DOAJ |
| description | The aim of the present study is to analyze the dynamics of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery. We showed that the concentration of free circulating mtDNA of blood tends to decrease 24 hours after ligation; it increased and reached values close to control samples 48 and 72 hours after ligation. These data define the need in further investigation of the dynamics of this parameter during later periods of myocardial infarction modeling that will contribute to objective evaluation of its significance for acute myocardial damage diagnostics and prognosis. |
| format | Article |
| id | doaj-art-3df5895331e240799c27ea9ad5814529 |
| institution | Kabale University |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2013-09-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-3df5895331e240799c27ea9ad58145292025-08-20T03:56:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962013-09-01051501531608Acute myocardial ischemia: changes of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary arteryN. P. Sudakov0T. P. Popkova1A. I. Katyshev2O. A. Goldberg3M. A. Novikova4S. B. Nikiforov5B. G. Pushkarev6I. V. Klimenkov7S. A. Lepekhova8K. A. Apartsin9S. D. Ezhikeeva10M. N. Ten11Yu. M. Konstantinov12Scientific Center of Reconstructive and Restorative Surgery SB RAMS; Irkutsk Regional Clinical Hospital; Limnological Institute SB RAS; Irkutsk State UniversityIrkutsk Regional Clinical HospitalSiberian Institute of Plant Physiology and Biochemistry SB RASScientific Center of Reconstructive and Restorative Surgery SB RAMSScientific Center of Reconstructive and Restorative Surgery SB RAMSScientific Center of Reconstructive and Restorative Surgery SB RAMSScientific Center of Reconstructive and Restorative Surgery SB RAMSLimnological Institute SB RAS; Irkutsk State UniversityScientific Center of Reconstructive and Restorative Surgery SB RAMS; Irkutsk Scientific Center SB RAMSScientific Center of Reconstructive and Restorative Surgery SB RAMS; Irkutsk Scientific Center SB RAMSIrkutsk Regional Clinical HospitalIrkutsk Regional Clinical HospitalSiberian Institute of Plant Physiology and Biochemistry SB RAS; Irkutsk State UniversityThe aim of the present study is to analyze the dynamics of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery. We showed that the concentration of free circulating mtDNA of blood tends to decrease 24 hours after ligation; it increased and reached values close to control samples 48 and 72 hours after ligation. These data define the need in further investigation of the dynamics of this parameter during later periods of myocardial infarction modeling that will contribute to objective evaluation of its significance for acute myocardial damage diagnostics and prognosis.https://www.actabiomedica.ru/jour/article/view/1662occlusion of the left coronary arterymyocardial ischemiamtdna levelbiomarkers of cardiomyocite cytolysisreal time pcr |
| spellingShingle | N. P. Sudakov T. P. Popkova A. I. Katyshev O. A. Goldberg M. A. Novikova S. B. Nikiforov B. G. Pushkarev I. V. Klimenkov S. A. Lepekhova K. A. Apartsin S. D. Ezhikeeva M. N. Ten Yu. M. Konstantinov Acute myocardial ischemia: changes of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery Acta Biomedica Scientifica occlusion of the left coronary artery myocardial ischemia mtdna level biomarkers of cardiomyocite cytolysis real time pcr |
| title | Acute myocardial ischemia: changes of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery |
| title_full | Acute myocardial ischemia: changes of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery |
| title_fullStr | Acute myocardial ischemia: changes of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery |
| title_full_unstemmed | Acute myocardial ischemia: changes of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery |
| title_short | Acute myocardial ischemia: changes of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery |
| title_sort | acute myocardial ischemia changes of free circulating mtdna level in blood after occlusion of the upper one third left descending branch of the coronary artery |
| topic | occlusion of the left coronary artery myocardial ischemia mtdna level biomarkers of cardiomyocite cytolysis real time pcr |
| url | https://www.actabiomedica.ru/jour/article/view/1662 |
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