Gut microbiota therapy in gastrointestinal diseases
The human gut microbiota, consisting of trillions of microorganisms, plays a crucial role in gastrointestinal (GI) health and disease. Dysbiosis, an imbalance in microbial composition, has been linked to a range of GI disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (I...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1514636/full |
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| author | Hanif Ullah Safia Arbab Chengting Chang Saira Bibi Nehaz Muhammad Sajid Ur Rehman Suleman Suleman Irfan Ullah Inam Ul Hassan Yali Tian Ka Li |
| author_facet | Hanif Ullah Safia Arbab Chengting Chang Saira Bibi Nehaz Muhammad Sajid Ur Rehman Suleman Suleman Irfan Ullah Inam Ul Hassan Yali Tian Ka Li |
| author_sort | Hanif Ullah |
| collection | DOAJ |
| description | The human gut microbiota, consisting of trillions of microorganisms, plays a crucial role in gastrointestinal (GI) health and disease. Dysbiosis, an imbalance in microbial composition, has been linked to a range of GI disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, and colorectal cancer. These conditions are influenced by the interactions between the gut microbiota, the host immune system, and the gut-brain axis. Recent research has highlighted the potential for microbiome-based therapeutic strategies, such as probiotics, prebiotics, fecal microbiota transplantation (FMT), and dietary modifications, to restore microbial balance and alleviate disease symptoms. This review examines the role of gut microbiota in the pathogenesis of common gastrointestinal diseases and explores emerging therapeutic approaches aimed at modulating the microbiome. We discuss the scientific foundations of these interventions, their clinical effectiveness, and the challenges in their implementation. The review underscores the therapeutic potential of microbiome-targeted treatments as a novel approach to managing GI disorders, offering personalized and alternative options to conventional therapies. As research in this field continues to evolve, microbiome-based interventions hold promise for improving the treatment and prevention of gastrointestinal diseases. |
| format | Article |
| id | doaj-art-3df51627e9a34e63b959d3d2c4b708dc |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-3df51627e9a34e63b959d3d2c4b708dc2025-08-20T03:11:22ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-02-011310.3389/fcell.2025.15146361514636Gut microbiota therapy in gastrointestinal diseasesHanif Ullah0Safia Arbab1Chengting Chang2Saira Bibi3Nehaz Muhammad4Sajid Ur Rehman5 Suleman6 Suleman7Irfan Ullah8Inam Ul Hassan9Yali Tian10Ka Li11Medicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, Nursing Key Laboratory of Sichuan Province, West China Hospital, West China School of Nursing, Sichuan University, Chengdu, Sichuan, ChinaLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, ChinaMedicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, Nursing Key Laboratory of Sichuan Province, West China Hospital, West China School of Nursing, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Zoology Hazara University Manshera, Dhodial, PakistanHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Collaborative Innovation Center for Eco-Environment, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei, ChinaSchool of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Zoology, Government Post Graduate Collage, Swabi, PakistanHigher Education Department, Civil Secretariat Peshawar, Peshawar, PakistanDepartment of Biotechnology and Genetics Engineering, Hazara University, Manshera, PakistanDepartment of Microbiology, Hazara University Manshera, Manshera, PakistanMedicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, Nursing Key Laboratory of Sichuan Province, West China Hospital, West China School of Nursing, Sichuan University, Chengdu, Sichuan, ChinaMedicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, Nursing Key Laboratory of Sichuan Province, West China Hospital, West China School of Nursing, Sichuan University, Chengdu, Sichuan, ChinaThe human gut microbiota, consisting of trillions of microorganisms, plays a crucial role in gastrointestinal (GI) health and disease. Dysbiosis, an imbalance in microbial composition, has been linked to a range of GI disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, and colorectal cancer. These conditions are influenced by the interactions between the gut microbiota, the host immune system, and the gut-brain axis. Recent research has highlighted the potential for microbiome-based therapeutic strategies, such as probiotics, prebiotics, fecal microbiota transplantation (FMT), and dietary modifications, to restore microbial balance and alleviate disease symptoms. This review examines the role of gut microbiota in the pathogenesis of common gastrointestinal diseases and explores emerging therapeutic approaches aimed at modulating the microbiome. We discuss the scientific foundations of these interventions, their clinical effectiveness, and the challenges in their implementation. The review underscores the therapeutic potential of microbiome-targeted treatments as a novel approach to managing GI disorders, offering personalized and alternative options to conventional therapies. As research in this field continues to evolve, microbiome-based interventions hold promise for improving the treatment and prevention of gastrointestinal diseases.https://www.frontiersin.org/articles/10.3389/fcell.2025.1514636/fullgut microbiotagastrointestinal diseasescancertherapydysbiosis |
| spellingShingle | Hanif Ullah Safia Arbab Chengting Chang Saira Bibi Nehaz Muhammad Sajid Ur Rehman Suleman Suleman Irfan Ullah Inam Ul Hassan Yali Tian Ka Li Gut microbiota therapy in gastrointestinal diseases Frontiers in Cell and Developmental Biology gut microbiota gastrointestinal diseases cancer therapy dysbiosis |
| title | Gut microbiota therapy in gastrointestinal diseases |
| title_full | Gut microbiota therapy in gastrointestinal diseases |
| title_fullStr | Gut microbiota therapy in gastrointestinal diseases |
| title_full_unstemmed | Gut microbiota therapy in gastrointestinal diseases |
| title_short | Gut microbiota therapy in gastrointestinal diseases |
| title_sort | gut microbiota therapy in gastrointestinal diseases |
| topic | gut microbiota gastrointestinal diseases cancer therapy dysbiosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1514636/full |
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