Ultra-sensitive aptameric field-effect transistor for cortisol sensing
Existing diagnostic methods for major depressive disorders, emerging mental disorders globally, are restrictive and inaccurate due to the lack of evidence-based assessments. Recent developments incorporating advanced material, micro/nano manufacturing and biology enable new clinical pathways using b...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Sensors and Actuators Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666053925000426 |
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| author | Thi Thanh Ha Nguyen Cong Minh Nguyen Minh Anh Huynh Quang Thang Trinh Philip Tanner Sven Ingebrandt Xuan Thang Vu Tuan-Khoa Nguyen Nam-Trung Nguyen |
| author_facet | Thi Thanh Ha Nguyen Cong Minh Nguyen Minh Anh Huynh Quang Thang Trinh Philip Tanner Sven Ingebrandt Xuan Thang Vu Tuan-Khoa Nguyen Nam-Trung Nguyen |
| author_sort | Thi Thanh Ha Nguyen |
| collection | DOAJ |
| description | Existing diagnostic methods for major depressive disorders, emerging mental disorders globally, are restrictive and inaccurate due to the lack of evidence-based assessments. Recent developments incorporating advanced material, micro/nano manufacturing and biology enable new clinical pathways using biosensors that can provide new opportunities for the diagnosis of mental condition from an early developmental stage. In this work, we present an ultra-sensitive lab-on-chip biosensor platform that is capable of detecting cortisol, a key biomarker for depression in physiological fluid. Utilizing advanced microfabrication techniques, our biosensor achieves a compact footprint of 5.0 mm by 2.5 mm, making it suitable for integration into portable and wearable devices. The device exhibits an ultra-low detection limit of 1 fM and a wide dynamic detection range spanning from 1 fM to 1 µM, covering the concentration present in physiological body fluids of human. Our finding shows a great potential for the development of accurate, and point-of-care monitoring system for early detection of depression disorders to advance the mental health diagnosis. |
| format | Article |
| id | doaj-art-3df41d70b86b4d31afae87d192f12020 |
| institution | DOAJ |
| issn | 2666-0539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensors and Actuators Reports |
| spelling | doaj-art-3df41d70b86b4d31afae87d192f120202025-08-20T03:06:05ZengElsevierSensors and Actuators Reports2666-05392025-06-01910032410.1016/j.snr.2025.100324Ultra-sensitive aptameric field-effect transistor for cortisol sensingThi Thanh Ha Nguyen0Cong Minh Nguyen1Minh Anh Huynh2Quang Thang Trinh3Philip Tanner4Sven Ingebrandt5Xuan Thang Vu6Tuan-Khoa Nguyen7Nam-Trung Nguyen8Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia; School of Engineering and Built Environment, Griffith University, Nathan, QLD 4111, AustraliaQueensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia; School of Environment and Science, Griffith University, Nathan, QLD 4111, AustraliaQueensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia; School of Engineering and Built Environment, Griffith University, Nathan, QLD 4111, AustraliaQueensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, AustraliaQueensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, AustraliaInstitute of Materials in Electrical Engineering 1, RWTH Aachen University, Sommerfeldstr. 24, Aachen 52074, GermanyInstitute of Materials in Electrical Engineering 1, RWTH Aachen University, Sommerfeldstr. 24, Aachen 52074, Germany; Corresponding authors.Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia; Corresponding authors.Queensland Micro- and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia; Corresponding authors.Existing diagnostic methods for major depressive disorders, emerging mental disorders globally, are restrictive and inaccurate due to the lack of evidence-based assessments. Recent developments incorporating advanced material, micro/nano manufacturing and biology enable new clinical pathways using biosensors that can provide new opportunities for the diagnosis of mental condition from an early developmental stage. In this work, we present an ultra-sensitive lab-on-chip biosensor platform that is capable of detecting cortisol, a key biomarker for depression in physiological fluid. Utilizing advanced microfabrication techniques, our biosensor achieves a compact footprint of 5.0 mm by 2.5 mm, making it suitable for integration into portable and wearable devices. The device exhibits an ultra-low detection limit of 1 fM and a wide dynamic detection range spanning from 1 fM to 1 µM, covering the concentration present in physiological body fluids of human. Our finding shows a great potential for the development of accurate, and point-of-care monitoring system for early detection of depression disorders to advance the mental health diagnosis.http://www.sciencedirect.com/science/article/pii/S2666053925000426Field effect transistorAptamerFET sensorCortisolBody fluidsLab on chip |
| spellingShingle | Thi Thanh Ha Nguyen Cong Minh Nguyen Minh Anh Huynh Quang Thang Trinh Philip Tanner Sven Ingebrandt Xuan Thang Vu Tuan-Khoa Nguyen Nam-Trung Nguyen Ultra-sensitive aptameric field-effect transistor for cortisol sensing Sensors and Actuators Reports Field effect transistor Aptamer FET sensor Cortisol Body fluids Lab on chip |
| title | Ultra-sensitive aptameric field-effect transistor for cortisol sensing |
| title_full | Ultra-sensitive aptameric field-effect transistor for cortisol sensing |
| title_fullStr | Ultra-sensitive aptameric field-effect transistor for cortisol sensing |
| title_full_unstemmed | Ultra-sensitive aptameric field-effect transistor for cortisol sensing |
| title_short | Ultra-sensitive aptameric field-effect transistor for cortisol sensing |
| title_sort | ultra sensitive aptameric field effect transistor for cortisol sensing |
| topic | Field effect transistor Aptamer FET sensor Cortisol Body fluids Lab on chip |
| url | http://www.sciencedirect.com/science/article/pii/S2666053925000426 |
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