Engineering Saccharomyces cerevisiae for medical applications
Abstract Background During the last decades, the advancements in synthetic biology opened the doors for a profusion of cost-effective, fast, and ecologically friendly medical applications priorly unimaginable. Following the trend, the genetic engineering of the baker’s yeast, Saccharomyces cerevisia...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Microbial Cell Factories |
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| Online Access: | https://doi.org/10.1186/s12934-024-02625-5 |
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| author | Carla Maneira Alexandre Chamas Gerald Lackner |
| author_facet | Carla Maneira Alexandre Chamas Gerald Lackner |
| author_sort | Carla Maneira |
| collection | DOAJ |
| description | Abstract Background During the last decades, the advancements in synthetic biology opened the doors for a profusion of cost-effective, fast, and ecologically friendly medical applications priorly unimaginable. Following the trend, the genetic engineering of the baker’s yeast, Saccharomyces cerevisiae, propelled its status from an instrumental ally in the food industry to a therapy and prophylaxis aid. Main text In this review, we scrutinize the main applications of engineered S. cerevisiae in the medical field focusing on its use as a cell factory for pharmaceuticals and vaccines, a biosensor for diagnostic and biomimetic assays, and as a live biotherapeutic product for the smart in situ treatment of intestinal ailments. An extensive view of these fields' academic and commercial developments as well as main hindrances is presented. Conclusion Although the field still faces challenges, the development of yeast-based medical applications is often considered a success story. The rapid advances in synthetic biology strongly support the case for a future where engineered yeasts play an important role in medicine. |
| format | Article |
| id | doaj-art-3de7629edbcb4b479abc683df0984a33 |
| institution | Kabale University |
| issn | 1475-2859 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbial Cell Factories |
| spelling | doaj-art-3de7629edbcb4b479abc683df0984a332025-01-12T12:45:42ZengBMCMicrobial Cell Factories1475-28592025-01-0124112510.1186/s12934-024-02625-5Engineering Saccharomyces cerevisiae for medical applicationsCarla Maneira0Alexandre Chamas1Gerald Lackner2Chair of Biochemistry of Microorganisms, Faculty of Life Sciences: Food, Nutrition and Health, University of BayreuthDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection BiologyChair of Biochemistry of Microorganisms, Faculty of Life Sciences: Food, Nutrition and Health, University of BayreuthAbstract Background During the last decades, the advancements in synthetic biology opened the doors for a profusion of cost-effective, fast, and ecologically friendly medical applications priorly unimaginable. Following the trend, the genetic engineering of the baker’s yeast, Saccharomyces cerevisiae, propelled its status from an instrumental ally in the food industry to a therapy and prophylaxis aid. Main text In this review, we scrutinize the main applications of engineered S. cerevisiae in the medical field focusing on its use as a cell factory for pharmaceuticals and vaccines, a biosensor for diagnostic and biomimetic assays, and as a live biotherapeutic product for the smart in situ treatment of intestinal ailments. An extensive view of these fields' academic and commercial developments as well as main hindrances is presented. Conclusion Although the field still faces challenges, the development of yeast-based medical applications is often considered a success story. The rapid advances in synthetic biology strongly support the case for a future where engineered yeasts play an important role in medicine.https://doi.org/10.1186/s12934-024-02625-5YeastCell factoryPharmaceuticalNatural productVaccineBiosensor |
| spellingShingle | Carla Maneira Alexandre Chamas Gerald Lackner Engineering Saccharomyces cerevisiae for medical applications Microbial Cell Factories Yeast Cell factory Pharmaceutical Natural product Vaccine Biosensor |
| title | Engineering Saccharomyces cerevisiae for medical applications |
| title_full | Engineering Saccharomyces cerevisiae for medical applications |
| title_fullStr | Engineering Saccharomyces cerevisiae for medical applications |
| title_full_unstemmed | Engineering Saccharomyces cerevisiae for medical applications |
| title_short | Engineering Saccharomyces cerevisiae for medical applications |
| title_sort | engineering saccharomyces cerevisiae for medical applications |
| topic | Yeast Cell factory Pharmaceutical Natural product Vaccine Biosensor |
| url | https://doi.org/10.1186/s12934-024-02625-5 |
| work_keys_str_mv | AT carlamaneira engineeringsaccharomycescerevisiaeformedicalapplications AT alexandrechamas engineeringsaccharomycescerevisiaeformedicalapplications AT geraldlackner engineeringsaccharomycescerevisiaeformedicalapplications |