Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective
Multi-dimensional studies have consistently indicated the benefits of dietary proanthocyanidins on blood glucose homeostasis through consumption of them from fruits, cereals and nuts. Proanthocyanidins from various sources possess different structures, but even the minor variations in structures inf...
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Elsevier
2024-01-01
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| Series: | Current Research in Food Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927124002533 |
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| author | Yi Wang Laiming Zhang Hang Xiao Xingqian Ye Haibo Pan Shiguo Chen |
| author_facet | Yi Wang Laiming Zhang Hang Xiao Xingqian Ye Haibo Pan Shiguo Chen |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | Multi-dimensional studies have consistently indicated the benefits of dietary proanthocyanidins on blood glucose homeostasis through consumption of them from fruits, cereals and nuts. Proanthocyanidins from various sources possess different structures, but even the minor variations in structures influence their regulation on blood glucose, including the degree of polymerization, galloacylation at C3, number of hydroxyl groups in B ring and linkage type. Therefore, this Review details the role of three types of proanthocyanidins (procyanidins, prodelphinidins and propelargonidins) in blood glucose control and their underlying mechanisms, and various structural features contribute to. Due to the extremely low bioavailability, proanthocyanidins mainly ameliorate high blood glucose by luminal effects: inhibit enzyme activities, improve the structure of gut microbiota, and protect the intestinal barrier function. A few absorbed proanthocyanidins exert insulin-like effects on targeted organs. Prodelphinidin gallates exhibit greater hypoglycemic activities than others, due to their galloacylation at C3 and high amounts of hydroxyl groups in B ring. Because of different action pathways, comprehensive consideration on the degree of polymerization, linkage type and density of hydroxyl groups was required. Further understanding of these relationships can concrete diet therapeutic opportunities for proanthocyanidins. |
| format | Article |
| id | doaj-art-3de69426b7ee41e6ad495a17ceabd084 |
| institution | OA Journals |
| issn | 2665-9271 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj-art-3de69426b7ee41e6ad495a17ceabd0842025-08-20T01:59:39ZengElsevierCurrent Research in Food Science2665-92712024-01-01910092610.1016/j.crfs.2024.100926Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspectiveYi Wang0Laiming Zhang1Hang Xiao2Xingqian Ye3Haibo Pan4Shiguo Chen5College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Laboratory of Food Technology and Equipment, Zhejiang University, Hangzhou, 310058, PR ChinaCollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Laboratory of Food Technology and Equipment, Zhejiang University, Hangzhou, 310058, PR ChinaCollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Laboratory of Food Technology and Equipment, Zhejiang University, Hangzhou, 310058, PR China; Department of Food Science, University of Massachusetts, Amherst, 01003, USACollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Laboratory of Food Technology and Equipment, Zhejiang University, Hangzhou, 310058, PR China; Zhejiang University Zhongyuan Institute, Zhengzhou, 450000, PR ChinaCollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Laboratory of Food Technology and Equipment, Zhejiang University, Hangzhou, 310058, PR China; Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, 314102, PR China; Corresponding author. Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, 314102, PR China.College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Laboratory of Food Technology and Equipment, Zhejiang University, Hangzhou, 310058, PR China; Zhejiang University Zhongyuan Institute, Zhengzhou, 450000, PR China; Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, 314102, PR China; Corresponding author. Zhejiang University Zhongyuan Institute, Zhengzhou, 450000, PR China.Multi-dimensional studies have consistently indicated the benefits of dietary proanthocyanidins on blood glucose homeostasis through consumption of them from fruits, cereals and nuts. Proanthocyanidins from various sources possess different structures, but even the minor variations in structures influence their regulation on blood glucose, including the degree of polymerization, galloacylation at C3, number of hydroxyl groups in B ring and linkage type. Therefore, this Review details the role of three types of proanthocyanidins (procyanidins, prodelphinidins and propelargonidins) in blood glucose control and their underlying mechanisms, and various structural features contribute to. Due to the extremely low bioavailability, proanthocyanidins mainly ameliorate high blood glucose by luminal effects: inhibit enzyme activities, improve the structure of gut microbiota, and protect the intestinal barrier function. A few absorbed proanthocyanidins exert insulin-like effects on targeted organs. Prodelphinidin gallates exhibit greater hypoglycemic activities than others, due to their galloacylation at C3 and high amounts of hydroxyl groups in B ring. Because of different action pathways, comprehensive consideration on the degree of polymerization, linkage type and density of hydroxyl groups was required. Further understanding of these relationships can concrete diet therapeutic opportunities for proanthocyanidins.http://www.sciencedirect.com/science/article/pii/S2665927124002533Dietary proanthocyanidinsBlood glucoseAbsorptionStructure |
| spellingShingle | Yi Wang Laiming Zhang Hang Xiao Xingqian Ye Haibo Pan Shiguo Chen Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective Current Research in Food Science Dietary proanthocyanidins Blood glucose Absorption Structure |
| title | Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective |
| title_full | Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective |
| title_fullStr | Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective |
| title_full_unstemmed | Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective |
| title_short | Revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi-scale structural perspective |
| title_sort | revisiting dietary proanthocyanidins on blood glucose homeostasis from a multi scale structural perspective |
| topic | Dietary proanthocyanidins Blood glucose Absorption Structure |
| url | http://www.sciencedirect.com/science/article/pii/S2665927124002533 |
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