An immortalized adipose-derived stem cells line from the PIK3CA-related overgrowth spectrum: Unveiling novel therapeutic targets

An immortalized adipose-derived stem cells line from the PIK3CA-related overgrowth spectrum: Unveiling novel therapeutic targets

PIK3CA-related overgrowth spectrum (PROS) encompasses several rare conditions that lead to overgrowth of various body parts resulting from activating variants in PIK3CA. The absence of ideal cell models significantly impedes progress in PROS research. In this study, we focused on facial infiltrating...

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Bibliographic Details
Main Authors: Bin Sun, Hongrui Chen, Wei Gao, Yunqi Li, Chen Hua, Xiaoxi Lin
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
PIK3CA-Related overgrowth spectrum
Facial infiltrating lipomatosis
Immortalization
ADSCs
Target therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580824002334
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