Association between soy products and prostate cancer: A systematic review and meta-analysis of observational studies
Purpose: The effect of soy products on prostate cancer (PCA) remains a topic of debate. This study aimed to investigate the association between soy products consumption and the incidence of PCA. Materials and Methods: A search was conducted in the PubMed, EBSCO, Web of Science, and Cochrane Library...
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Korean Urological Association
2024-11-01
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| Series: | Investigative and Clinical Urology |
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| Online Access: | https://www.icurology.org/pdf/10.4111/icu.20240186 |
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| author | Yiping Huang Wenyan Wang Jianxiang Jin |
| author_facet | Yiping Huang Wenyan Wang Jianxiang Jin |
| author_sort | Yiping Huang |
| collection | DOAJ |
| description | Purpose: The effect of soy products on prostate cancer (PCA) remains a topic of debate. This study aimed to investigate the association between soy products consumption and the incidence of PCA.
Materials and Methods: A search was conducted in the PubMed, EBSCO, Web of Science, and Cochrane Library databases up to December 2023. The adjusted odds ratio (OR) and corresponding 95% confidence interval (CI) were used to assess the association.
Results: A total of 22 articles, comprising 1,409,213 participants, were included for this meta-analysis. The results indicate that soy products reduce the risk of PCA (OR=0.94, 95% CI=0.91–0.97, p<0.001), especially in cases of localized or low-grade PCA (OR=0.94, 95% CI=0.90–0.97, p<0.001), but exhibit no effect on non-localized or high-grade PCA (OR=0.96, 95% CI=0.91–1.01, p=0.085). Furthermore, increased consumption frequency was negatively associated with PCA risk. Specifically, soy products can reduce the risk of PCA in African Americans (OR=0.89, p=0.006) and Latinos (OR=0.93, p=0.036), but have no impact on Japanese (OR=0.99, p=0.655), Chinese (OR=0.90, p=0.155), and Whites (OR=0.96, p=0.133). Non-fermented soy products were associated with a reduction in the incidence rate of PCA (OR=0.93, 95% CI=0.90–0.96, p<0.001), while fermented soy products had no effect on the incidence rate of PCA (OR=1.10, 95% CI=0.98–1.22, p=0.096).
Conclusions: The consumption of soy products can reduce the overall risk of PCA among men. Various factors, including soy products-related factors (e.g., consumption, frequency), population-related factors (e.g., race), and PCA-related factors (e.g., PCA stage) collectively influence the effect of soy products on PCA. |
| format | Article |
| id | doaj-art-3ddcd5b571ec402499c2b86fa1479d2a |
| institution | OA Journals |
| issn | 2466-0493 2466-054X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj-art-3ddcd5b571ec402499c2b86fa1479d2a2025-08-20T02:12:34ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2024-11-0165654055010.4111/icu.20240186Association between soy products and prostate cancer: A systematic review and meta-analysis of observational studiesYiping Huang0https://orcid.org/0009-0000-8005-8496Wenyan Wang1https://orcid.org/0009-0009-4318-5213Jianxiang Jin2https://orcid.org/0009-0008-2934-3038Department of Urology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, China.Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.Purpose: The effect of soy products on prostate cancer (PCA) remains a topic of debate. This study aimed to investigate the association between soy products consumption and the incidence of PCA. Materials and Methods: A search was conducted in the PubMed, EBSCO, Web of Science, and Cochrane Library databases up to December 2023. The adjusted odds ratio (OR) and corresponding 95% confidence interval (CI) were used to assess the association. Results: A total of 22 articles, comprising 1,409,213 participants, were included for this meta-analysis. The results indicate that soy products reduce the risk of PCA (OR=0.94, 95% CI=0.91–0.97, p<0.001), especially in cases of localized or low-grade PCA (OR=0.94, 95% CI=0.90–0.97, p<0.001), but exhibit no effect on non-localized or high-grade PCA (OR=0.96, 95% CI=0.91–1.01, p=0.085). Furthermore, increased consumption frequency was negatively associated with PCA risk. Specifically, soy products can reduce the risk of PCA in African Americans (OR=0.89, p=0.006) and Latinos (OR=0.93, p=0.036), but have no impact on Japanese (OR=0.99, p=0.655), Chinese (OR=0.90, p=0.155), and Whites (OR=0.96, p=0.133). Non-fermented soy products were associated with a reduction in the incidence rate of PCA (OR=0.93, 95% CI=0.90–0.96, p<0.001), while fermented soy products had no effect on the incidence rate of PCA (OR=1.10, 95% CI=0.98–1.22, p=0.096). Conclusions: The consumption of soy products can reduce the overall risk of PCA among men. Various factors, including soy products-related factors (e.g., consumption, frequency), population-related factors (e.g., race), and PCA-related factors (e.g., PCA stage) collectively influence the effect of soy products on PCA.https://www.icurology.org/pdf/10.4111/icu.20240186dietmeta-analysisprostatic neoplasmsrisk assessmentsoy foods |
| spellingShingle | Yiping Huang Wenyan Wang Jianxiang Jin Association between soy products and prostate cancer: A systematic review and meta-analysis of observational studies Investigative and Clinical Urology diet meta-analysis prostatic neoplasms risk assessment soy foods |
| title | Association between soy products and prostate cancer: A systematic review and meta-analysis of observational studies |
| title_full | Association between soy products and prostate cancer: A systematic review and meta-analysis of observational studies |
| title_fullStr | Association between soy products and prostate cancer: A systematic review and meta-analysis of observational studies |
| title_full_unstemmed | Association between soy products and prostate cancer: A systematic review and meta-analysis of observational studies |
| title_short | Association between soy products and prostate cancer: A systematic review and meta-analysis of observational studies |
| title_sort | association between soy products and prostate cancer a systematic review and meta analysis of observational studies |
| topic | diet meta-analysis prostatic neoplasms risk assessment soy foods |
| url | https://www.icurology.org/pdf/10.4111/icu.20240186 |
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