Design and synthesis of amino-substituted N-arylpiperidinyl-based inhibitors of the (immuno)proteasome

Design and synthesis of amino-substituted N-arylpiperidinyl-based inhibitors of the (immuno)proteasome

The constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. The development of novel chemical scaffolds of non-peptidic nature, capable of inhibiting diffe...

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Main Authors: Gobec Martina, Obreza Aleš, Jukič Marko, Baumgartner Ana, Mihelčič Nja, Potočnik Špela, Virant Julija, Mlinarič Irena, Stanislav Raščan, Sosič Gobec Izidor
Format: Article
Language:English
Published: Sciendo 2023-09-01
Series:Acta Pharmaceutica
Subjects:
proteasomes
scaffold morphing
optimization
computational design
selectivity
inhibitors
Online Access:https://doi.org/10.2478/acph-2023-0032
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https://doi.org/10.2478/acph-2023-0032

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