Integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds
Abstract This study aimed to integrate transcriptomes to reveal the regulatory molecular mechanisms of meat quality in different black goat breeds. A comparison of Guizhou Black Goats (GBG♂, n = 7), Black Nubian Goats (NBG♂, n = 7), and their F1 hybrids (FBG♂, GB♀ × NB♂, n = 7) revealed that the FBG...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00476-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849235676693790720 |
|---|---|
| author | Yong Long Naifeng Zhang Yanliang Bi Tao Ma Pramote Paengkoum Wen Xiao Yanpin Zhao Chao Yuan Defeng Wang Yang Yang Chaozhi Su Yong Han |
| author_facet | Yong Long Naifeng Zhang Yanliang Bi Tao Ma Pramote Paengkoum Wen Xiao Yanpin Zhao Chao Yuan Defeng Wang Yang Yang Chaozhi Su Yong Han |
| author_sort | Yong Long |
| collection | DOAJ |
| description | Abstract This study aimed to integrate transcriptomes to reveal the regulatory molecular mechanisms of meat quality in different black goat breeds. A comparison of Guizhou Black Goats (GBG♂, n = 7), Black Nubian Goats (NBG♂, n = 7), and their F1 hybrids (FBG♂, GB♀ × NB♂, n = 7) revealed that the FBG demonstrated notable improvements in meat quality parameters, muscle fiber traits, fatty acid and amino acid compositions, mineral content, intramuscular fat (IMF), and inosine monophosphate (IMP) levels. Moreover, transcriptome analysis identified 119, 77, and 82 differentially expressed genes (DEGs) in the GBG vs NBG, FBG vs GBG, and FBG vs NBG comparisons, respectively. Among these, 111, 74, and 82 DEGs were associated with IMF deposition, and 61, 34, and 32 DEGs were linked to IMP deposition, respectively. Of particular note, the analysis pinpointed key genes related to IMF (PFKM and FZD4) and IMP (AMPD3, ENPP1, ENTPD1, ENTPD8, and PRPS2), laying a solid data groundwork for future research aimed at enhancing the meat quality of black goats. |
| format | Article |
| id | doaj-art-3dd9b218cffe42968b4fef32aadc8d54 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-3dd9b218cffe42968b4fef32aadc8d542025-08-20T04:02:42ZengNature Portfolionpj Science of Food2396-83702025-07-019111410.1038/s41538-025-00476-xIntegrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breedsYong Long0Naifeng Zhang1Yanliang Bi2Tao Ma3Pramote Paengkoum4Wen Xiao5Yanpin Zhao6Chao Yuan7Defeng Wang8Yang Yang9Chaozhi Su10Yong Han11Guizhou University of Traditional Chinese MedicineInstitute of Feed Research of Chinese Academy of Agricultural ScienceInstitute of Feed Research of Chinese Academy of Agricultural ScienceInstitute of Feed Research of Chinese Academy of Agricultural ScienceSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of TechnologyInstitute of Animal Husbandry and Veterinary Sciences, Guizhou Academy of Agricultural SciencesInstitute of Animal Husbandry and Veterinary Sciences, Guizhou Academy of Agricultural SciencesInstitute of Animal Husbandry and Veterinary Sciences, Guizhou Academy of Agricultural SciencesInstitute of Animal Husbandry and Veterinary Sciences, Guizhou Academy of Agricultural SciencesInstitute of Animal Husbandry and Veterinary Sciences, Guizhou Academy of Agricultural SciencesInstitute of Animal Husbandry and Veterinary Sciences, Guizhou Academy of Agricultural SciencesGuizhou University of Traditional Chinese MedicineAbstract This study aimed to integrate transcriptomes to reveal the regulatory molecular mechanisms of meat quality in different black goat breeds. A comparison of Guizhou Black Goats (GBG♂, n = 7), Black Nubian Goats (NBG♂, n = 7), and their F1 hybrids (FBG♂, GB♀ × NB♂, n = 7) revealed that the FBG demonstrated notable improvements in meat quality parameters, muscle fiber traits, fatty acid and amino acid compositions, mineral content, intramuscular fat (IMF), and inosine monophosphate (IMP) levels. Moreover, transcriptome analysis identified 119, 77, and 82 differentially expressed genes (DEGs) in the GBG vs NBG, FBG vs GBG, and FBG vs NBG comparisons, respectively. Among these, 111, 74, and 82 DEGs were associated with IMF deposition, and 61, 34, and 32 DEGs were linked to IMP deposition, respectively. Of particular note, the analysis pinpointed key genes related to IMF (PFKM and FZD4) and IMP (AMPD3, ENPP1, ENTPD1, ENTPD8, and PRPS2), laying a solid data groundwork for future research aimed at enhancing the meat quality of black goats.https://doi.org/10.1038/s41538-025-00476-x |
| spellingShingle | Yong Long Naifeng Zhang Yanliang Bi Tao Ma Pramote Paengkoum Wen Xiao Yanpin Zhao Chao Yuan Defeng Wang Yang Yang Chaozhi Su Yong Han Integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds npj Science of Food |
| title | Integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds |
| title_full | Integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds |
| title_fullStr | Integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds |
| title_full_unstemmed | Integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds |
| title_short | Integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds |
| title_sort | integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds |
| url | https://doi.org/10.1038/s41538-025-00476-x |
| work_keys_str_mv | AT yonglong integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT naifengzhang integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT yanliangbi integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT taoma integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT pramotepaengkoum integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT wenxiao integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT yanpinzhao integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT chaoyuan integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT defengwang integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT yangyang integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT chaozhisu integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds AT yonghan integratedtranscriptomicanalysisunveilsmolecularmechanismsregulatingmeatqualityinnewlyimprovedblackgoatbreeds |