Engineering of ovarian tissue for ovarian dysfunctions: A review
This review explores tissue engineering as a potential solution for reproductive health issues in women caused by genetic or acquired diseases, such as premature ovarian failure or oophorectomy. The loss of ovarian function can lead to infertility, osteoporosis, and cardiovascular disease. Hormone r...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Asian Pacific Journal of Reproduction |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/apjr.apjr_81_23 |
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| author | Aliya Zhylkybekova Gulbakit K. Koshmaganbetova Myltykbay S. Rysmakhanov Nurgul Abdullayevna Abenova Nadiar Maratovich Mussin Asset Askerovich Kaliyev Mahdi Mahdipour Amin Tamadon |
| author_facet | Aliya Zhylkybekova Gulbakit K. Koshmaganbetova Myltykbay S. Rysmakhanov Nurgul Abdullayevna Abenova Nadiar Maratovich Mussin Asset Askerovich Kaliyev Mahdi Mahdipour Amin Tamadon |
| author_sort | Aliya Zhylkybekova |
| collection | DOAJ |
| description | This review explores tissue engineering as a potential solution for reproductive health issues in women caused by genetic or acquired diseases, such as premature ovarian failure or oophorectomy. The loss of ovarian function can lead to infertility, osteoporosis, and cardiovascular disease. Hormone replacement therapy is a common treatment, but it has limitations and risks. The review focuses on two main approaches in tissue engineering: scaffold-based (3D printing, electrospinning, decellularization) and scaffold-free (stem cell transplantation, organoid cultivation). Both approaches show promise in preclinical studies for creating functional ovarian tissue. Challenges include vascularization, innervation, long-term function, and safety. Despite these challenges, tissue engineering offers a potential avenue for restoring fertility and hormone balance in women with ovarian dysfunction. |
| format | Article |
| id | doaj-art-3dd7b9f146284ed08491437f4e244557 |
| institution | Kabale University |
| issn | 2305-0500 2305-0519 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Reproduction |
| spelling | doaj-art-3dd7b9f146284ed08491437f4e2445572025-01-08T13:16:10ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002305-05192024-01-0113131110.4103/apjr.apjr_81_23Engineering of ovarian tissue for ovarian dysfunctions: A reviewAliya ZhylkybekovaGulbakit K. KoshmaganbetovaMyltykbay S. RysmakhanovNurgul Abdullayevna AbenovaNadiar Maratovich MussinAsset Askerovich KaliyevMahdi MahdipourAmin TamadonThis review explores tissue engineering as a potential solution for reproductive health issues in women caused by genetic or acquired diseases, such as premature ovarian failure or oophorectomy. The loss of ovarian function can lead to infertility, osteoporosis, and cardiovascular disease. Hormone replacement therapy is a common treatment, but it has limitations and risks. The review focuses on two main approaches in tissue engineering: scaffold-based (3D printing, electrospinning, decellularization) and scaffold-free (stem cell transplantation, organoid cultivation). Both approaches show promise in preclinical studies for creating functional ovarian tissue. Challenges include vascularization, innervation, long-term function, and safety. Despite these challenges, tissue engineering offers a potential avenue for restoring fertility and hormone balance in women with ovarian dysfunction.https://journals.lww.com/10.4103/apjr.apjr_81_23female gonadstissue engineeringestrogenreproductive system |
| spellingShingle | Aliya Zhylkybekova Gulbakit K. Koshmaganbetova Myltykbay S. Rysmakhanov Nurgul Abdullayevna Abenova Nadiar Maratovich Mussin Asset Askerovich Kaliyev Mahdi Mahdipour Amin Tamadon Engineering of ovarian tissue for ovarian dysfunctions: A review Asian Pacific Journal of Reproduction female gonads tissue engineering estrogen reproductive system |
| title | Engineering of ovarian tissue for ovarian dysfunctions: A review |
| title_full | Engineering of ovarian tissue for ovarian dysfunctions: A review |
| title_fullStr | Engineering of ovarian tissue for ovarian dysfunctions: A review |
| title_full_unstemmed | Engineering of ovarian tissue for ovarian dysfunctions: A review |
| title_short | Engineering of ovarian tissue for ovarian dysfunctions: A review |
| title_sort | engineering of ovarian tissue for ovarian dysfunctions a review |
| topic | female gonads tissue engineering estrogen reproductive system |
| url | https://journals.lww.com/10.4103/apjr.apjr_81_23 |
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